NOVEL NEURONAL SIGNALING MODULE

新型神经信号模块

• 批准号: 6394346
• 负责人: MITCHELL GOLDFARB
• 金额: $ 41.58万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394346
• 关键词: biological signal transduction; cell growth regulation; developmental neurobiology; genetically modified animals; growth factor; laboratory mouse; neural plasticity; neurophysiology; protein kinase; protein structure function

DESCRIPTION (From the applicant's abstract): Nervous system development and function are regulated by neuronal responses to an extensive repertoire of extracellular molecular stimuli. These stimuli influence neuronal cell survival, differentiation, axonal guidance, synapse formation, synaptic plasticity, and neurophysiological responses through an array of signal transduction mechanisms which are still poorly understood. My laboratory has uncovered a novel signaling module within neuronal cells that consists of a newly discovered protein kinase scaffold protein, a cascade of protein kinases, and a set of proteins previously thought to function extracellularly as growth factors. The experiments proposed within this application are expected to identify extracellular stimuli that signal through this novel kinase module and to determine the neurobiological consequences of this signaling pathway. In addition to the importance of defining the architecture and regulation of a new biochemical pathway, these studies are likely to significantly improve our understanding of mechanisms underlying neuronal development and function.

描述（来自申请人摘要）：神经系统发育和