Effects of pin biomechanics, coating material and surface roughness on the pin-bone interface in external repair

有些骨折需要外固定，用金属钉固定在骨片中。治疗总体上是成功的，尽管针道经常松动并被感染。这种并发症可能危及骨折愈合，必须治疗。本项目的目的是确定销设计的哪些方面容易导致销-骨界面上的这些问题。是针最初插入的方式，也许不够紧，导致针不稳定，或者太紧，导致骨头微裂缝？是针的材料，可以用生物活性涂层来改善吗？是不是表面粗糙度导致了骨细胞的不同反应？有一个抗生素胸针会有帮助吗？这项提议就是为了回答这些问题。针的生物力学将首先通过计算机模型进行研究，然后在实验室进行测试。然后，将对不同类型的销子的松动和感染进行生物学研究。研究结果将阐明针的生物力学、涂层和表面粗糙度的作用，从而改进设计并改善骨折患者的结果。

Some fractures require external fixation, anchored with metal pins in the bone fragments. The reatment is generally successful, although the pin tracts often loosen and become infected. This complication may jeopardise fracture healing and must be treated. The purpose of this project is to determine what aspects of pin design predispose to these problems at the pin-bone interface. Is it the way the pins are initially inserted, perhaps not tightly enough so that the pin is unstable, or perhaps too tight, causing microcracks in the bone? Is it the material of the pin, which might be improved with a bioactive coating? Is it the surface roughness which causes different responses of bone cells? Would it help to have an antibiotic pin? This proposal is designed to answer these questions. The biomechanics of the pin will first be studied with computer models and then tested in the laboratory. The loosening and infection associated with different types of pin will then be studied biologically. The results of the study will clarify the roles of pin biomechanics, coating and surface roughness, leading to improvements in design and better outcomes in fracture patients.