The Epidemiology of Marine Fatty Acids and Preeclampsia

描述：(申请人提供)先兆子痫的病因不明。 简而言之，来自几项研究的结果(通常是不对照的小规模研究 用于混淆)表明母体抗氧化剂和 促氧化状态可能与先兆子痫的风险增加有关。 也有新的证据表明，母体之间存在联系 促炎症状态和先兆子痫的风险增加。在这场竞争中 ，我们希望在这项工作的基础上，继续 前瞻性研究(海洋脂肪酸和先兆子痫的流行病学：RO 1 HD 32562)，并战略性地整合新的生物标记，这将有助于 更好地描述先兆子痫的流行病学特征。这项研究是一项队列研究 对1500名怀孕早期登记的孕妇进行的研究 送货。我们计划将这一群体扩大到包括总共4,200人 未经的妇女。我们将使用嵌套病例队列设计和多变量 应用Logistic分析方法评估子痫前期发病风险 含有母体抗氧化剂的生物标记物(酶和非酶) 状态。此外，我们还将评估有关母亲慢性病的假说 促炎状态[用高敏C反应蛋白衡量 (HS-CRP)和包括肿瘤坏死因子-a在内的促炎细胞因子 可溶性受体(sTNFp55和sTNFp75)与子痫前期的关系 风险。我们的总体目标是测试饮食、免疫学和 其他生活方式特征与随后的高血压风险有关 发展为先兆子痫。我们努力的结果应该会提供额外的 关于内皮功能障碍的机制基础和 先兆子痫的风险。此外，我们的结果应该提供可能 用于推动预防干预策略的发展 足以影响先兆子痫的发生。调查结果： 拟议的研究可能对开发替代方案具有实际意义， 对先兆子痫和其他不良反应的实用预防性干预 妊娠结局(例如，胎儿发育迟缓和早产)。 抗氧化剂，以及锌和硒等痕量金属(它们很重要 对抗氧化酶的活性)，以及铁可以很容易 在饮食中通过补充剂的使用或特定的食物选择来操纵 如果这项研究和其他研究的证据表明有好处的话。

DESCRIPTION: (provided by applicant) The etiology of preeclampsia is unknown. Briefly, results from several studies (typically small studies not controlling for confounding) suggest that an imbalance in maternal antioxidant and pro-oxidant status may be associated with an increased risk of preeclampsia. There is also emerging evidence suggestive of an association between maternal proinflammatory status and increased risk of preeclampsia. In this competing renewal application, we seek to build on this body of work by continuing the prospective study (Epidemiology of Marine Fatty Acids and Preeclampsia: RO 1 HD 32562), and strategically integrating new biological markers that will serve to better characterize the epidemiology of preeclampsia. The study is a cohort study of 1,500 pregnant women enrolled early in pregnancy and followed until delivery. We plan to expand this cohort to include enrolling a total of 4,200 nulliparous women. We will use a nested case-cohort design and multivariate logistic analytical methods to assess the relation between risk of preeclampsia with biological markers of maternal antioxidant (enzymatic and non-enzymatic) status. Additionally, we will assess hypotheses concerning maternal chronic pro-inflammatory status [as measured by high sensitivity C-reactive protein (hs-CRP) and the pro-inflammatory cytokines including tumor necrosis factor-a (TNF-a)] soluble receptors (sTNFp55 and sTNFp75) in relation to preeclampsia risk. Our overall objective is to test whether dietary, immunological, and other lifestyle characteristics are associated with subsequent risk of developing preeclampsia. Results from our efforts should provide additional knowledge concerning the mechanistic basis for endothelial dysfunction and preeclampsia risk. Furthermore, our results should provide information that may be used to motivate the development of prevention intervention strategies sufficient for impacting the occurrence of preeclampsia. Results from the proposed study could have practical significance in developing alternative, practical preventative interventions for preeclampsia and other adverse pregnancy outcomes (e.g., fetal growth retardation and preterm delivery). Antioxidants, and trace metals such as zinc and selenium (which are important to the activity of antioxidant enzymes), as well as iron could be easily manipulated in the diet either by supplement use or by specific choice of foods if evidence from this and other studies indicates a benefit.