PERIVASCULAR BRAIN MACROPHAGES ARE MAJOR TARGET OF SIV INFECTION
PERIVASCULAR BRAIN MACROPHAGES ARE MAJOR TARGET OF SIV INFECTION
批准号:
6453757
负责人:
KENNETH C WILLIAMS
金额:
$11.11万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-05-01 至 2002-04-30
中文摘要
不同单核细胞/巨噬细胞群体的鉴定
英文摘要
The identification of distinct monocyte/macrophage populations
that carry virus to the CNS and subsets within the CNS that are the
target for infection by HIV/SIV is not defined In this study we have
used immunohistochemistry and combined immunohistochemistry with in
situ hybridization to define which populations of brain macrophages
are infected at peak viremia and in SIVE Perivascular brain
macrophages and the resident brain macrophage, microglia, are both
CDllb and CD68 positive The perivascular macrophages, but not
microglia, are also positive for CD14, CD45, and CD86 Multi-nucleated
giant cells (MNGC), when present, are CD11b and CD68 positive like
parenchymal microglia and perivascular macrophages The MNGC also are
CD14 and CD45 positive, but express variable to non-detectable levels
of CD4 Using combined immunohistochemistry and in situ hybridization
and/or double label immunohistochemistry for myeloid cell markers
followed by gp120, we demonstrat e th at the majority of gp120 or
viral RNA positive cells are CD14 positive perivascular macrophages
These perivascular cells are the major cell infected within the CNS
during peak viremia (2 weeks post infection) and in animals with SIVE
Less than 1% of the infected cells are resident microglia based upon
immunohistochemistry These data underscore the importance of the
perivascular macrophage as the major target of SIV in the CNS
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会议论文
PERIPHERAL NEUROPATHY IN SIV-INFECTED CD8-DEPLETED RHESUS MACAQUES
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批准号:8358173
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:KENNETH C WILLIAMS
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依托单位:
MONOCYTE TRAFFIC AND NEUROPATHOGENESIS OF AIDS
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批准号:8357961
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项目类别:
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资助金额:$6.84万
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财政年份:2011
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负责人:KENNETH C WILLIAMS
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依托单位:
MONOCYTE TRAFFIC AND NEUROPATHOGENESIS OF AIDS
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批准号:8172876
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项目类别:
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资助金额:$6.58万
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财政年份:2010
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负责人:KENNETH C WILLIAMS
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依托单位:
MONOCYTE TRAFFIC AND NEUROPATHOGENESIS OF AIDS
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批准号:7958395
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项目类别:
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资助金额:$11.19万
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财政年份:2009
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负责人:KENNETH C WILLIAMS
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依托单位:
CD8+ T LYMPHOCYTES IN SIMIAM IMMUNODEFICIENCY VIRUS ENCEPHALITIS
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批准号:7165131
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项目类别:
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资助金额:$5.62万
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财政年份:2005
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负责人:KENNETH C WILLIAMS
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依托单位:
PCNA EXPRESSION AS A MARKER OF PERIVASCULAR MACROPHAGES IN SIV ENCEPHALITIS
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批准号:6939833
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项目类别:
-
资助金额:$6.15万
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财政年份:2003
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负责人:KENNETH C WILLIAMS
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依托单位:
PERIVASCULAR BRAIN MACROPHAGES ARE MAJOR TARGET OF SIV INFECTION
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批准号:6591311
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项目类别:
-
资助金额:$11.11万
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财政年份:2002
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负责人:KENNETH C WILLIAMS
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依托单位:
INHIBITION OF EAE W/ MONOCLONAL ANTIBODY THAT RECOGNIZES NOVEL ANTIGEN
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批准号:6591312
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项目类别:
-
资助金额:$11.11万
-
财政年份:2002
-
负责人:KENNETH C WILLIAMS
-
依托单位:
INHIBITION OF EAE W/ MONOCLONAL ANTIBODY THAT RECOGNIZES NOVEL ANTIGEN
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批准号:6453758
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项目类别:
-
资助金额:$11.11万
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财政年份:2001
-
负责人:KENNETH C WILLIAMS
-
依托单位:
MONOCYTE TRAFFIC AND THE NEUROPATHOGENESIS OF AIDS
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批准号:6505415
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项目类别:
-
资助金额:$5.0万
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财政年份:1999
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负责人:KENNETH C WILLIAMS
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依托单位:
Monocyte Traffic and Neuropathogenesis of AIDS
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批准号:8424880
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项目类别:
-
资助金额:$59.09万
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财政年份:1999
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负责人:KENNETH C WILLIAMS
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依托单位:
Monocyte Traffic and Neuropathogenesis of AIDS
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批准号:7899884
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项目类别:
-
资助金额:$43.47万
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财政年份:1999
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负责人:KENNETH C WILLIAMS
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依托单位:
Monocyte Traffic and Neuropathogenesis of AIDS
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批准号:8497755
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项目类别:
-
资助金额:$55.66万
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财政年份:1999
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负责人:KENNETH C WILLIAMS
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依托单位:
Monocyte Traffic and Neuropathogenesis of AIDS
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批准号:7482964
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项目类别:
-
资助金额:$56.95万
-
财政年份:1999
-
负责人:KENNETH C WILLIAMS
-
依托单位:
MONOCYTE TRAFFIC AND THE NEUROPATHOGENESIS OF AIDS
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批准号:6642727
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项目类别:
-
资助金额:$31.6万
-
财政年份:1999
-
负责人:KENNETH C WILLIAMS
-
依托单位:
Monocyte Traffic and Neuropathogenesis of AIDS
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批准号:8703810
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项目类别:
-
资助金额:$57.1万
-
财政年份:1999
-
负责人:KENNETH C WILLIAMS
-
依托单位:
Monocyte Traffic and Neuropathogenesis of AIDS
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批准号:9104228
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项目类别:
-
资助金额:$42.38万
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财政年份:1999
-
负责人:KENNETH C WILLIAMS
-
依托单位:
Monocyte Traffic and Neuropathogenesis of AIDS
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批准号:7684652
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项目类别:
-
资助金额:$62.34万
-
财政年份:1999
-
负责人:KENNETH C WILLIAMS
-
依托单位:
MONOCYTE TRAFFIC AND THE NEUROPATHOGENESIS OF AIDS
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批准号:6348769
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项目类别:
-
资助金额:$28.92万
-
财政年份:1999
-
负责人:KENNETH C WILLIAMS
-
依托单位:
MONOCYTE TRAFFIC AND THE NEUROPATHOGENESIS OF AIDS
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批准号:6188478
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项目类别:
-
资助金额:$29.78万
-
财政年份:1999
-
负责人:KENNETH C WILLIAMS
-
依托单位:
海外基金