Experimental Mechanistic Studies of Catalytic Reactions

催化反应的实验机理研究

• 批准号: 1932957
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1932957
• 关键词: Experimental; Mechanistic; Studies; Catalytic; Reactions

To identify the change in distribution of molecular species within the reaction media to determine how the substrate and catalyst make their transition to product liberation. In situ methods will provide a means to monitor species concentration over the course of the reaction which may help in identifying; any competing reacting pathways by assignment of their intermediates and products, ; resting state of the catalyst from the species distribution, ; insight into the rate-limiting step within the catalytic cycle, which will provide a means to identify any factors which will assist or perturb the efficacy of the cycle and ; orders of the reaction with respect to molecular species involved by applying the VTNA method. The in situ methods will primarily involve NMR, an invaluable, quantitative method in itself, with the added benefit that the nuclei under scrutiny, 1H and 19F, are of naturally high abundance.

确定反应介质中分子种类分布的变化，以确定底物和催化剂如何过渡到产物释放。原位方法将提供一种监测反应过程中物质浓度的方法，这可以帮助识别：通过分配它们的中间体和产物来识别任何竞争反应途径;从物质分布来识别催化剂的静止状态;深入了解催化循环中的限速步骤，这将提供一种手段来鉴定任何有助于或干扰循环效率的因素，以及通过应用VTNA方法涉及的分子种类的反应顺序。原位方法将主要涉及NMR，这本身是一种非常宝贵的定量方法，其额外的好处是，受审查的核1H和19 F具有天然的高丰度。