Nanoprobes for Molecule-Specific Contrast Enhancement

描述(由申请人提供)：建议开发纳米拉曼探测器，以便于检测单个分子的拉曼散射。拟议的第一阶段研究将侧重于纳米颗粒系统和分析物-纳米颗粒复合体的合理设计。纳米颗粒-固态支撑平台也将在拟议的研究中进行优化。在第一阶段的研究中，将建立一种分析复杂细胞系统中单分子振动光谱的策略的可行性。这项研究将导致开发一种具有分析单个分子结构能力的市场分析系统。我们相信，一个强大灵敏的拉曼系统的可用性将引起化学和生物医学研究人员的广泛兴趣。它可能会对DNA测序、早期疾病检测和环境监测产生影响。

DESCRIPTION (provided by applicant): Development of nano-Raman probes that will facilitate the detection of Raman scattering of individual molecule is proposed. The proposed phase I research will focus on the rational design of a nanoparticle system and analyte-nanoparticle complex. The nanoparticle-solid state support platform will also be optimized in the proposed research. During the phase I research the feasibility of a strategy for analyzing single molecule vibrational spectrum in complex cellular system will be established. This research will lead to the development of a marketable analytical system with the capability of analyzing the structure of an individual molecule. We believe that the availability of a robust sensitive Raman system will have broad interest from chemical and biomedical researchers. And it might have impact on DNA sequencing, early stage disease detection, and environmental monitoring.