Novel Dense Hollow Fiber for Blood-Gas Exchange

描述（由申请人提供）：我们设计了一种技术， 大大简化了致密硅树脂的制造并使其具有成本效益 用于气体交换应用的纤维 生命支持、植入式人工肺和其他心肺功能 程序.该技术允许生产无孔的、高性能的， 和经济上有吸引力的紧凑型气体交换装置，类似于它们的 微孔膜中空纤维（MMHF）对应物。器械包含 MMHF已经变得流行，主要是因为增强的气体交换， 血液流过数千个微小的空洞时引起的对流混合 纤维该性质允许设计高效的气体交换 体积相对紧凑的设备。然而，MMHF遭受家禽，和血浆 当它们长时间使用时， 当气体侧压力超过血液侧压力时进行气体栓塞。 因此结合了中空纤维的紧凑性和有效性 具有固体硅树脂膜的能力， 血浆泄漏和气体栓塞是膜中所需的性质 设计的血液氧合。在第一阶段，我们建议进一步发展 制作技术，并评估气体交换和血液动力学 在原型中作为交换的致密中空纤维的性能 装置. 拟定商业应用：仅在美国，每年就有超过750，000名患者接受某种形式的需要气体交换装置的心肺支持。本装置将消除微孔膜式氧合器中可能发生的血浆泄漏和气体栓塞的可能性。

DESCRIPTION (provided by applicant): We have devised a technique that will greatly simplify and make cost effective the fabrication of dense silicone fibers for use in gas exchange applications including long-term extracorporeal life support, implantable artificial lung, and other cardiorespiratory procedures. The technique allows for producing, non-porous, high performing, and economically attractive compact gas exchange devices, analogous to their microporous membrane hollow fibers (MMHF) counterparts. Devices incorporating MMHF have become popular mainly because of enhanced gas exchange due to the convective mixing induced by blood flowing over thousands of tiny hollow fibers. This property allows for designing highly efficient gas exchange devices in relatively compact volumes. Yet MMHF suffer from fowling, and plasma leakage when they are used for extended periods of time, and from propensity to gas embolization when the gas side pressure exceeds the blood side pressure. Thus incorporating the compactness and effectiveness of hollow fibers configuration with the ability of solid silicone membranes to withstanding plasma leakage and gas embolization are desirable properties in a membrane designed blood oxygenation. In Phase 1 we propose to further develop the fabrication technique and to evaluate the gas exchange and hemodynamic performance of the dense hollow fibers incorporated in prototype as exchange devices. PROPOSED COMMERCIAL APPLICATION: In the US alone over 750,000 patients a year receive some form of cardiorespiratory support requring gas exchange devices. The present device will eliminate the possibility of plasma leakage and gas embolization which are possible in microporous membrane oxygenators.