Novel Dense Hollow Fiber for Blood-Gas Exchange

用于血气交换的新型致密中空纤维

• 批准号: 6883970
• 负责人: Jean Montoya
• 金额: $ 17.9万
• 依托单位: MEDARRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883970
• 关键词: artificial membranes; biomedical equipment development; blood oxygenator; circulatory assist; extracorporeal circulation; hemodynamics; hollow fiber separation technique; respiratory gas transport; sheep; silicon compounds; technology /technique development

DESCRIPTION (provided by applicant): We have devised a technique that will greatly simplify and make cost effective the fabrication of dense silicone membrane hollow fibers (SMHF) for use in blood gas exchange applications including long-term extracorporeal life support, implantable artificial lung, and other cardiorespiratory procedures. The SMHF can be used to make non-porous, high performing, and economically attractive compact oxygenators, analogous to microporous membrane hollow fiber (MMHF) devices. Current devices using MMHF are prevalent because of enhanced gas exchange due to the convective mixing induced by blood flowing over thousands of tiny hollow fibers. This property allows for designing highly efficient gas exchange devices in relatively compact volumes. Yet MMHF suffer from fowling, and plasma leakage when they are used for extended periods of time, and from gas embolization when the gas side pressure exceeds the blood side pressure. Nonetheless there is currently no analogous non-microporous hollow fiber oxygenators. The present SMHF incorporates the compactness and effectiveness of MMHFs plus the ability to withstand plasma leakage and gas embolization. In Phase 1 we demonstrated that the SMHF can be fabricated continuously and reliably using our proprietary process, and that test oxygenating modules using our SMHF perform comparably to the MMHF counterparts. In Phase 2 we propose to further develop and scale-up the fabrication technique to evaluate the gas exchange, hemodynamic performance, and resistance to plasma breakthrough of the SMHF in adult size oxygenators. These studies will be performed on the bench as well as in-vivo.

描述（由申请人提供）： 我们设计了一种技术，可以极大地简化并使成本效益，以制造密集的硅胶膜中空纤维（SMHF），用于血液气体换应用，包括长期的体外生命支持，可植入的人造肺和其他心脏呼吸程序。 SMHF可用于制造非孔，高性能且经济上有吸引力的紧凑型氧化剂，类似于微孔膜纤维纤维（MMHF）设备。使用MMHF的当前设备由于流动超过数千个微小的空心纤维引起的对流混合而导致气体交换增强。该属性允许在相对紧凑的体积中设计高效的气体交换设备。然而，MMHF在长时间使用时会遭受杂音和血浆泄漏的影响，当气体压力超过血液侧压力时，气体栓塞均受气体栓塞。尽管如此，目前尚无类似的非微孔空心纤维氧合。目前的SMHF结合了MMHF的紧凑性和有效性，以及承受血浆泄漏和气体栓塞的能力。在第1阶段，我们证明了SMHF可以使用我们的专有过程连续而可靠地制造，并且可以使用我们的SMHF与MMHF对应物进行相当的性能测试含氧模块。在第2阶段，我们建议进一步开发和扩大制造技术，以评估成人大小的氧化剂中SMHF的气体动力学性能以及对血浆突破的抵抗力。这些研究将在板凳和体内进行。