MOLECULAR EPIDEMIOLOGY OF PROSTATE CARCINOGENESIS

前列腺癌发生的分子流行病学

• 批准号: 6513071
• 负责人: Timothy Robert Church
• 金额: $ 39.31万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6513071
• 关键词: agriculture; alcoholic beverage consumption; blood chemistry; cancer risk; carcinogenesis; clinical research; diet; dietary lipid; genetic markers; human subject; interview; loss of heterozygosity; male; molecular oncology; neoplasm /cancer epidemiology; occupations; pesticides; prostate neoplasms; racial /ethnic difference; tobacco abuse

DESCRIPTION: (Adapted from the Investigator's Abstract) The goals of this proposed project are to identify risk factors for prostate cancer, to identify specific genetic and biochemical markers associated with prostate cancer, and to identify relationships between risk factors and biomarkers. The study will utilize a case-control design. In-person interviews will be used to collect data on prostate cancer risk factors such as race, family history, medical history, diet, alcohol, tobacco use, and occupation (including farming-related exposures). Blood samples from cases and controls and tissue samples from cases will be analyzed for biochemical and genetic markers hypothesized to be associated with prostate cancer. The following specific hypotheses will be investigated: (1) Increased intake of dietary fat, pesticide exposure, farming, family history of prostate cancer, or race are associated with prostate cancer risk. (2) Certain genetic markers are associated with increased frequency based on exposure variables leading to an increased risk of prostate cancer. (3) Farming and occupational pesticide exposure are related to increases in the frequency of loss of heterozygosity of chromosomes 8, 10 , and 17. (4) High levels of dietary fat intake are associated with high androgen levels. Cases will be all Minnesota and Wisconsin incident men diagnosed with prostate cancers, aged 80 or less, over a two-year time period. An equal number of controls will be selected from state driver's license records and frequency matched to cases on age and state. Cases and controls under the age of 60 will serve as the primary group of interest although all cases will be compared to all controls.

描述：（改编自研究者摘要） 建议的项目是确定前列腺癌的危险因素， 与前列腺癌相关的特异性遗传和生化标志物，以及 以确定风险因素和生物标志物之间的关系。这项研究将 采用病例对照设计。将通过面对面访谈收集 关于前列腺癌风险因素的数据，如种族、家族史、医疗 病史、饮食、酒精、烟草使用和职业（包括与农业有关的 曝光）。病例和对照的血液样本以及病例的组织样本 将分析生化和遗传标记，假设是 与前列腺癌相关。以下具体假设将 调查：（1）膳食脂肪摄入量增加，农药暴露，农业， 前列腺癌家族史或种族与前列腺癌相关 风险(2)某些遗传标记与基于 暴露变量导致前列腺癌风险增加。（三） 农业和职业农药接触与 8、10和17号染色体杂合性丢失的频率。(4)高 膳食脂肪摄入水平与高雄激素水平有关。例 将是明尼苏达州和威斯康星州所有被诊断为前列腺疾病的男性 80岁或以下的癌症患者，在两年的时间内。相等数量的 控制将从国家驾驶执照记录和频率选择 与年龄和状态上的病例相匹配60岁以下的病例和对照组将 作为主要关注组，尽管所有病例都将与 所有控制。

项目成果

Quantifying lead-time bias in risk factor studies of cancer through simulation.

• DOI: 10.1016/j.annepidem.2013.07.021
• 发表时间: 2013-11
• 期刊: ANNALS OF EPIDEMIOLOGY
• 影响因子: 5.6
• 作者: Jansen, Rick J.;Alexander, Bruce H.;Anderson, Kristin E.;Church, Timothy R.
• 通讯作者: Church, Timothy R.