Non-Invasive Pneumothorax Detector

无创气胸检测仪

• 批准号: 6443541
• 负责人: GEOFFREY M KOTZAR
• 金额: $ 49.19万
• 依托单位: ELECTROSONICS MEDICAL INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443541
• 关键词: biomedical equipment development; clinical research; diagnosis design /evaluation; diagnosis quality /standard; human subject; miniature biomedical equipment; noninvasive diagnosis; patient monitoring device; pneumothorax disorder; portable biomedical equipment; radiowave radiation; respiratory disorder diagnosis

Pneumothorax, while easily treatable, can become life threatening if not detected at any early stage. Current methods for diagnosing pneumothorax (chest x-ray, chest CT scan) are not possible for emergency squads and not practical for long-term monitoring of critical care patients. A portable handheld pneumothorax detector that is inexpensive, accurate, and non-invasive therefore would be very attractive. In Phase I, we investigated the feasibility of such a device, based on micropower impulse radar (MIR) technology. In animal studies (swine model), we are determined that pneumothorax as small as 30 ml were clearly detectable by the MIR device. This level of detection is important for the feasibility, since it is below the threshold of clinical significance. In Phase II, we propose to further optimize the MIR characteristics of the device and the signal algorithms. We will then acquire scans on human subjects to confirm the correlation of the MIR measure to the chest x-ray, which is the present standard of care. After finalizing the device parameters, we will continue with device development, miniaturization, and packaging. This research will result in a design ready for commercialization that fulfills the need for a non- invasive pneumothorax detector. PROPOSED COMMERCIAL APPLICATIONS: A handheld inexpensive pneumothorax will be commercially attractive to emergency medical personnel and trauma clinicians. Also, it would be useful for patient monitoring in critical care units. The combined market for these applications if very large. With further development, the device may be tunable to detect other trauma conditions, such as hemotoma and hemorrhagic stroke.

气胸虽然易于治疗，但如果在任何早期阶段未发现生命，可能会威胁生命。当前用于诊断气胸（胸部X射线，胸部CT扫描）的方法是紧急小队的可能性，而对于长期监测重症监护患者是不可能的。因此，便宜的手持式气胸检测器是廉价，准确且无创的，这将非常有吸引力。在第一阶段，我们根据微型冲动雷达（MIR）技术研究了这种设备的可行性。在动物研究（猪模型）中，我们确定MiR装置可以清楚地检测到小至30 mL的气胸。这种检测水平对于可行性很重要，因为它低于临床意义的阈值。在第二阶段，我们建议进一步优化设备的MIR特性和信号算法。然后，我们将对人类受试者进行扫描，以确认MIR度量与胸部X射线的相关性，这是当前的护理标准。完成设备参数后，我们将继续进行设备开发，小型化和包装。这项研究将导致准备商业化的设计，以满足对非侵入性气胸检测器的需求。拟议的商业应用：手持式廉价的气胸对紧急医疗人员和创伤临床医生将在商业上具有吸引力。此外，这对于重症监护病房的患者监测将很有用。如果很大，这些应用程序的组合市场。随着进一步的发展，该装置可能可调节以检测其他创伤状况，例如血流瘤和出血性中风。