Ultrasound and Nerve Stimulator Guide

超声和神经刺激器指南

• 批准号: 6525445
• 负责人: LAWRENCE J BUSSE
• 金额: $ 21.83万
• 依托单位: LJB DEVELOPMENT, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6525445
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biomedical equipment safety; biophysics; cardiovascular imaging /visualization; cardiovascular system; clinical trials; conduction anesthesia; disease /disorder prevention /control; drug delivery systems; electrical measurement; electronic stimulator; human subject; human therapy evaluation; intravenous anesthesia; neuromuscular stimulator; outcomes research; patient oriented research; peripheral nervous system; postoperative complications; surgery material /equipment; time resolved data

DESCRIPTION (Provided by the Applicant): Regional anesthesia (RA) is a powerful technique to reduce both perioperative and chronic pain. RA provides significant benefits to patients since it requires only light sedation and thereby results in a low incidence of postoperative complications. Despite these advantages, only 5-20 percent of eligible patients receives RA. Selection for RA depends primarily on a practitioner's confidence in applying the method. The proposed research will develop a device that will improve physician confidence by providing realtime feedback during RA. The success of the block: depends on locating the deeply placed nerves for peripheral nerve blockade or the neurovaseular bundle for plexus blockade, while avoiding surrounding vital structures. Since target nerves lie in close proximity to major blood vessels, guidance will be provided using a combination of Doppler ultrasound (for long-range direction) and electrical nerve stimulation for confirmation of needle placement. A Doppler Directed Nerve Stimulator (DDNS) using the continuous-wave Doppler method will be built and a clinical study undertaken to study its efficacy for guiding RA. A DDNS prototype using pulsed-wave Doppler will be built and tested for improved performance and safe about. Successful completion of Phase II will lead to the introduction of a new product for RA delivery. PROPOSED COMMERCIAL APPLICATION: RA potentially benefits both patients and payers since its use promotes rapid recovery, shortened hospital stays and excellent pain control. The overall cost of RA is about 1/3 of costs associated with general anesthesia. The development of a disposable device for guiding RA will result in a commercially viable product, which will increase the use of RA and decrease the costs associated with surgical anesthesia and post-operative care.

描述（由申请人提供）：区域麻醉（RA）是强大的 减少围手术期和慢性疼痛的技术。 RA提供 对患者的重大好处，因为它仅需要轻镇静和 从而导致术后并发症发生率低。尽管 这些优点，只有5-20％的合格患者接受RA。选择 因为RA主要取决于从业者对应用该方法的信心。 拟议的研究将开发一种将改善医师的设备 通过在RA期间提供实时反馈来信心。块的成功： 取决于定位深处的神经以进行周围神经阻滞或 神经植物束，用于丛封锁，同时避免了周围 结构。由于靶神经与主要血管非常接近，因此 将使用多普勒超声的组合提供指导（对于 远程方向）和电神经刺激以确认 针头放置。多普勒使用该指示神经刺激剂（DDN） 将建立连续波多普勒方法，并进行临床研究 研究其指导RA的功效。 DDNS原型使用脉冲波多普勒 将建立和测试，以提高性能和安全。成功的 第二阶段的完成将导致引入RA的新产品 送货。 拟议的商业应用： RA可能受益于患者和付款人，因为其使用促进了快速 恢复，缩短医院住宿和极好的疼痛控制。总成本 RA的大约是与全身麻醉相关的成本的1/3。发展 用于指导RA的一次性设备将导致商业上可行的产品， 这将增加RA的使用并降低与手术相关的成本 麻醉和术后护理。