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中文摘要
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描述(由申请人提供):局部麻醉(RA)是一种强有力的 减少围手术期和慢性疼痛的技术。RA提供 对患者有显著的益处,因为它只需要轻度镇静, 从而导致术后并发症的发生率低。尽管 这些优点,只有5- 20%的合格患者接受RA。选择 对于RA,主要取决于从业者对应用该方法的信心。 这项拟议中的研究将开发一种设备, 在RA期间提供实时反馈。区块的成功: 取决于定位深置神经以进行外周神经阻滞,或者 神经血管束用于丛阻滞,同时避开周围重要的 结构.由于目标神经位于主血管附近, 将使用多普勒超声(用于 远程方向)和电神经刺激,以确认 针头放置。使用的多普勒定向神经刺激器(DDNS) 将建立连续波多普勒方法并进行临床研究, 研究其指导RA的有效性。脉冲多普勒DDNS原型系统 将建立和测试,以提高性能和安全约。成功 第二阶段的完成将导致引入一种新的RA产品 交付. 拟定商业应用: RA可能使患者和付款人受益,因为它的使用促进了快速 恢复,缩短住院时间和出色的疼痛控制。整体成本 RA的费用约为全身麻醉费用的1/3。发展 用于引导RA的一次性装置的使用将产生商业上可行的产品, 这将增加RA的使用,并降低与手术相关的费用, 麻醉和术后护理。
英文摘要
DESCRIPTION (Provided by the Applicant): Regional anesthesia (RA) is a powerful technique to reduce both perioperative and chronic pain. RA provides significant benefits to patients since it requires only light sedation and thereby results in a low incidence of postoperative complications. Despite these advantages, only 5-20 percent of eligible patients receives RA. Selection for RA depends primarily on a practitioner's confidence in applying the method. The proposed research will develop a device that will improve physician confidence by providing realtime feedback during RA. The success of the block: depends on locating the deeply placed nerves for peripheral nerve blockade or the neurovaseular bundle for plexus blockade, while avoiding surrounding vital structures. Since target nerves lie in close proximity to major blood vessels, guidance will be provided using a combination of Doppler ultrasound (for long-range direction) and electrical nerve stimulation for confirmation of needle placement. A Doppler Directed Nerve Stimulator (DDNS) using the continuous-wave Doppler method will be built and a clinical study undertaken to study its efficacy for guiding RA. A DDNS prototype using pulsed-wave Doppler will be built and tested for improved performance and safe about. Successful completion of Phase II will lead to the introduction of a new product for RA delivery. PROPOSED COMMERCIAL APPLICATION: RA potentially benefits both patients and payers since its use promotes rapid recovery, shortened hospital stays and excellent pain control. The overall cost of RA is about 1/3 of costs associated with general anesthesia. The development of a disposable device for guiding RA will result in a commercially viable product, which will increase the use of RA and decrease the costs associated with surgical anesthesia and post-operative care.
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Development of a rapid, scalable, and deployable point-of-care blood volume diagnostic for monitoring postpartum and trauma-related hemorrhage
  • 批准号:
    10603819
  • 项目类别:
  • 资助金额:
    $23.13万
  • 财政年份:
    2023
  • 负责人:
    LAWRENCE J BUSSE
  • 依托单位:
Ultrasound and Nerve Stimulator Guide
  • 批准号:
    6337470
  • 项目类别:
  • 资助金额:
    $21.31万
  • 财政年份:
    1999
  • 负责人:
    LAWRENCE J BUSSE
  • 依托单位:
ULTRASOUND AND NERVE STIMULATOR GUIDE
  • 批准号:
    2785411
  • 项目类别:
  • 资助金额:
    $9.96万
  • 财政年份:
    1999
  • 负责人:
    LAWRENCE J BUSSE
  • 依托单位:
REDUCED SPECKLE EFFECT ON ULTRASOUND LESION DETECTION
  • 批准号:
    3506777
  • 项目类别:
  • 资助金额:
    $25.83万
  • 财政年份:
    1990
  • 负责人:
    LAWRENCE J BUSSE
  • 依托单位: