Ultrasound and Nerve Stimulator Guide

描述(由申请人提供)：区域麻醉(RA)是一种强大的 减少围手术期和慢性疼痛的技术。RA提供 对患者有显著好处，因为它只需要轻微的镇静和 从而降低了术后并发症的发生率。尽管 这些优势，只有5%-20%的符合条件的患者会患上RA。选择 因为RA主要取决于实践者对应用该方法的信心。 这项拟议的研究将开发一种设备，将改善医生 通过在RA期间提供实时反馈来增强信心。该区块的成功： 取决于定位深部放置的神经以阻断周围神经或 神经血管束用于神经丛的阻断，同时避开周围的生命 结构。由于靶神经与主要血管紧密相连， 将结合使用多普勒超声(用于 远距离方向)和电刺激以确认 针头摆放。一种多普勒定向神经刺激器(DDNS) 将建立连续波多普勒法并进行临床研究 研究其对RA的指导作用。一种基于脉冲多普勒技术的DDNS样机 将进行建造和测试，以提高性能和安全性。成功 第二阶段的完成将导致为RA推出一种新产品 送货。 建议的商业应用： RA对患者和付款人都有潜在的好处，因为它的使用促进了 康复、缩短住院时间和出色的疼痛控制。总成本 约为全麻相关费用的1/3。最新进展 用于引导RA的一次性装置将产生商业上可行的产品， 这将增加RA的使用并降低与手术相关的成本 麻醉和术后护理。

DESCRIPTION (Provided by the Applicant): Regional anesthesia (RA) is a powerful technique to reduce both perioperative and chronic pain. RA provides significant benefits to patients since it requires only light sedation and thereby results in a low incidence of postoperative complications. Despite these advantages, only 5-20 percent of eligible patients receives RA. Selection for RA depends primarily on a practitioner's confidence in applying the method. The proposed research will develop a device that will improve physician confidence by providing realtime feedback during RA. The success of the block: depends on locating the deeply placed nerves for peripheral nerve blockade or the neurovaseular bundle for plexus blockade, while avoiding surrounding vital structures. Since target nerves lie in close proximity to major blood vessels, guidance will be provided using a combination of Doppler ultrasound (for long-range direction) and electrical nerve stimulation for confirmation of needle placement. A Doppler Directed Nerve Stimulator (DDNS) using the continuous-wave Doppler method will be built and a clinical study undertaken to study its efficacy for guiding RA. A DDNS prototype using pulsed-wave Doppler will be built and tested for improved performance and safe about. Successful completion of Phase II will lead to the introduction of a new product for RA delivery. PROPOSED COMMERCIAL APPLICATION: RA potentially benefits both patients and payers since its use promotes rapid recovery, shortened hospital stays and excellent pain control. The overall cost of RA is about 1/3 of costs associated with general anesthesia. The development of a disposable device for guiding RA will result in a commercially viable product, which will increase the use of RA and decrease the costs associated with surgical anesthesia and post-operative care.