LOW POWER,HIGH SENSITIVITY,ELECTRONIC OLFACTORY SENSORS

低功耗、高灵敏度电子嗅觉传感器

• 批准号: 6516215
• 负责人: LOUIS H STRONG
• 金额: $ 37.86万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-15 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516215
• 关键词: biomedical equipment development; fiber optics; fluorescent dye /probe; ionophores; microprocessor /microchip; monitoring device; odors; olfactions; olfactory stimulus

DESCRIPTION (Adapted from applicant's abstract): The structure-function paradigm of the diverse, sensitive, highly evolved, vertebrate olfactory pathway provides the foundation for electronic olfactory sensors. A particularly advantageous electronic olfactory sensor detects the changes in fluorescence from an indicator imbedded in a polymer produced by weak, non-specific interactions between the odor and an array of polymers. Unfortunately, instabilities caused by saturation effects and photobleaching, a result of the excessive excitation intensity necessary for an array of photodiode detectors, limit their sensitivity and overall performance. Based on recent advances in Geiger-mode micro-Avalanche Photodiode (uAPD) arrays at Radiation Monitoring Devices, Inc. (RMD) and olfactory sensors investigated at Tufts University, School of Medicine, we propose to develop a high sensitivity, low power, olfactory sensor. The fluorescence light will be detected by a uAPD array with single-photon sensitivity, enabling a substantial reduction in the incident excitation intensity. In Phase I we successfully investigated various substrates and demonstrated the feasibility of our sensor concept by constructing a simple Phase I prototype sensor. In Phase II, we will continue to research appropriate sensors, develop a prototype to meet the performance specifications determined in Phase I, and investigate the interactions between the odor, and the fluorophore imbedded polymer. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：结构功能 多样，敏感，高度演变的脊椎动物嗅觉的范式 途径为电子嗅觉传感器提供了基础。一个 特别有利的电子嗅觉传感器检测到的变化 荧光是从嵌入在弱的聚合物中的指标， 气味与一系列聚合物之间的非特异性相互作用。 不幸的是，饱和效果和光漂白引起的不稳定性，一个 阵列所需的过度激发强度的结果 光电二极管检测器，限制其灵敏度和整体性能。 基于Geiger模式微型Avalanche光电二极管（UAPD）的最新进展 辐射监控设备（RMD）和嗅觉传感器的阵列 在塔夫茨大学医学院进行了调查，我们建议开发 高灵敏度，低功率，嗅觉传感器。荧光将是 由具有单光子灵敏度的UAPD阵列检测到，实现了实质性 降低入射激发强度。 在第一阶段，我们成功研究了各种底物，并证明了 通过构建简单的I期原型，我们的传感器概念的可行性 传感器。在第二阶段，我们将继续研究适当的传感器，开发 一个原型，以满足在第一阶段确定的性能规格，以及 研究气味和荧光团之间的相互作用 聚合物。 拟议的商业应用： 无法使用