Activity-directed synthesis of bioactive small molecules

生物活性小分子的活性定向合成

• 批准号: 1939663
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1939663
• 关键词: Activity; directed; synthesis; bioactive; small

Activity-directed synthesis (ADS) is a novel discovery approach that we have developed in which novel bioactive small molecules emerge in parallel with associated syntheses. Distinctively, ADS harnesses the promiscuity of reactions that can yield alternative products. The project will involve the expansion of the platform of chemical reactions that are configured for activity-directed synthesis (ADS), and the exploitation of ADS in the discovery of novel and diverse small molecules with specific biological functions.

活性定向合成(ADS)是我们开发的一种新的发现方法，在合成的同时出现了新的生物活性小分子。独一无二的是，广告利用了可以产生替代产品的混合反应。该项目将涉及为活性定向合成(ADS)配置的化学反应平台的扩展，以及开发ADS以发现具有特定生物功能的新颖和多样化的小分子。