Investigation Of Key Inflammatory Cells & Mediators In Zebrafish Larval Tailfin & Heart Repair/regeneration Following Resolution Of Inflammation

关键炎症细胞的研究

• 批准号: 1939882
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1939882
• 关键词: Investigation; Key; Inflammatory; Cells; Mediators

Severe infections can develop into a life-threatening condition known as sepsis. Sepsis is a condition in which the body's immune system attacks itself, leading to organ failure. However, paradoxically, this condition is also associated with a failure of the immune system to kill invading bugs. The mechanisms which lead to this maladaptive state remain unclear, which hampers the development of effective treatments. One group of immune cells, called 'dendritic cells', act as a vital link between the body's first line of defence (the 'innate immune system') and the slower but more specific 'adaptive immune system'. We have recently identified an apparently novel subset of dendritic cells that are expanded in both patients with infection and, especially so, those with life-threatening sepsis. The aim of this project is to gain a fuller understanding of this subset of dendritic cells, to establish their functional role and their relationship to more established subsets. We also want to determine how their function is altered in infection and sepsis, and explore whether their function can be improved. This project will provide new insights into the processes that lead to sepsis, and thus help develop novel therapies to reduce the mortality from this serious condition.

严重的感染会发展成危及生命的败血症。败血症是一种身体免疫系统攻击自身，导致器官衰竭的疾病。然而，矛盾的是，这种情况也与免疫系统杀死入侵细菌的失败有关。导致这种不适应状态的机制尚不清楚，这阻碍了有效治疗的发展。一组被称为“树突状细胞”的免疫细胞，在人体的第一道防线（“先天免疫系统”）和较慢但更特异性的“适应性免疫系统”之间起着至关重要的作用。我们最近发现了一种明显新颖的树突状细胞亚群，它在感染患者和特别是那些危及生命的败血症患者中都有扩增。该项目的目的是获得更全面的了解这一子集的树突状细胞，建立其功能作用和它们的关系，更成熟的子集。我们还想确定它们的功能在感染和败血症中是如何改变的，并探索它们的功能是否可以改善。该项目将为导致败血症的过程提供新的见解，从而有助于开发新的疗法来降低这种严重疾病的死亡率。