Scottish Non Tuberculous Mycobacteria in Humans - a 15 Year Cohort

这个项目是关于苏格兰的非结核分枝杆菌（NTM）。我们将使用位于爱丁堡的苏格兰分枝杆菌参考实验室数据库，该数据库拥有15年来4100例NTM阳性样本，并与临床和流行病学数据相关联。与须呈报的结核分枝杆菌不同，国际上缺乏关于非结核分枝杆菌（NTM）引起的流行病学、发病率和死亡率的数据。NTM生活在环境中，但在免疫正常和免疫功能低下的儿童和成人中引起人类疾病。它们可以影响先前健康的个体，但更常影响有合并症的患者。ntm可引起肺部疾病，与结核分枝杆菌引起的疾病相同。本研究的目的如下：-评估自20世纪90年代末以来15年间苏格兰NTM的流行病学。-评估NTM在苏格兰的地理分布，因为我们有可用的邮政编码数据。-评估NTM分离株的临床意义、治疗方法和结果。-创建苏格兰NTM数据库。-发展研究伦理、良好临床规范、统计学、流行病学和数据管理方面的专业知识。-出席地方、国家和国际会议。-把研究结果发表在有声望的同行评议期刊上。

This project is on Non-Tuberculous Mycobacteria (NTM) in Scotland. We will be using the Scottish Mycobacterial Reference Laboratory database, in Edinburgh, which has 4100 positives samples of NTM over 15 years and linking with clinical and epidemiological data.Unlike Mycobacterium tuberculosis which is a notifiable disease, there is a paucity of data about the epidemiology, morbidity and mortality caused by non tuberculous mycobacteria (NTM) internationally. NTM live in the environment but cause human illness in both immunocompetent and immunocompromised children and adults. They can affect previously healthy individuals but more commonly affect patients with co-morbidities. NTMs can cause disease in the lungs identical to that caused by Mycobacterium tuberculosis.Aim of this study are as follows:-Evaluate the epidemiology of NTM in Scotland over a 15 year period from late 1990s. -Assess the geographic distribution of NTM in Scotland as we have postcode data available. -Assess the clinical significance of NTM isolates, treatment and outcomes.-To create a Scottish NTM database. -To develop expertise in research ethics, Good Clinical Practice, statistics, epidemiology and data management. -To present at local, national and international meetings. -To publish the research findings in a prestigious peer reviewed journal.