Linked Knowledge Model for Excellence in Bioinformatics

描述(申请人提供)：范德比尔特大学将在基因组学和蛋白质组学领域取得令人瞩目的科学进步--将创新的计算方法与基础生物科学的进步相结合。源源不断的新的定量技术和工具将使功能生物学取得进展；这一流取决于信息学、生物数学和计算机科学的研究结果。为了在这些新领域保持竞争力，领先的大学必须制定新的组织战略，以组建研究团队，保持研究人员的最新状态，并提供核心和基础设施支持。基础科学和计算方法的快速变化，以及研究的多学科性质，要求采取这种方法。范德比尔特提出了一个链接的知识模型作为一个组织框架，以创造一个在生物医学信息科学和技术方面的卓越环境，以最大限度地提高多学科研究的效率。这一模式的要素：1)跨机构战略的持续发展；2)使用由此产生的愿景来协调招聘，并将智力资本纳入灵活的问题解决团队；3)采用模块化教育计划，以迅速跨越边界转移新知识，为新手和成熟的研究人员服务；以及4)创建卓越中心，将传统支持核心与下一代技术、工具开发和教育的研究相结合。范德比尔特的Bisti规划项目将测试和完善链接知识组织模型的要素。它将展示典型的多学科科学项目，这些项目产生新的信息学和计算研究，以及解决具有挑战性的生物学问题的工具。它将使范德比尔特公司在生物医学计算方面建立一个全面的国家卓越计划。组织课程、工具/技术和生物学发现将广泛适用于范德比尔特以外的领域。

DESCRIPTION (provided by applicant): Vanderbilt University is positioned to achieve compelling scientific advancement in the areas of genomics and proteomics--combining innovative computational approaches with advances in basic biological science. A steady stream of new quantitative techniques and tools will enable progress in functional biology; this stream depends upon research results from informatics, biomathematics, and computer science. To stay competitive in these new arenas, leading universities must develop new organizational strategies for assembling research teams, keeping investigators current, and providing Core and infrastructure support. Rapid changes in basic science and computational methods, and the multidisciplinary nature of research, mandate such an approach. Vanderbilt proposes a Linked Knowledge Model as an organizational framework for creating an environment of excellence in biomedical information science and technology to maximize multidisciplinary research. Elements of this model: 1) on-going development of trans-institutional strategy; 2) use of the resulting vision to coordinate recruitment and incorporate intellectual capital into flexible problem solving teams; 3) adoption of modular education programs to move new knowledge rapidly across boundaries, serving both neophytes and established investigators; and, 4) creation of centers of excellence combining a traditional support Core with research into next generation techniques, tool development and education. Vanderbilt's BISTI planning project will test and refine the elements of the Linked Knowledge organization model. It will showcase prototypic multidisciplinary scientific projects that produce new informatics and computational research and tools to address challenging biological problems. It will position Vanderbilt to establish a full-scale national program of excellence in biomedical computing. Organizational lessons, tools/techniques, and biologic findings will be broadly applicable beyond Vanderbilt.