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Linked Knowledge Model for Excellence in Bioinformatics

卓越生物信息学的链接知识模型

基本信息

批准号：
6661965
负责人：
WILLIAM W STEAD
金额：
$ 40.41万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2005-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6661965
关键词：
clinical research computer program /software computer simulation enzyme inhibitors functional /structural genomics gene expression growth factor receptors informatics laboratory mouse microarray technology model model design /development oligonucleotides proteomics

项目摘要

DESCRIPTION (provided by applicant): Vanderbilt University is positioned to achieve compelling scientific advancement in the areas of genomics and proteomics--combining innovative computational approaches with advances in basic biological science. A steady stream of new quantitative techniques and tools will enable progress in functional biology; this stream depends upon research results from informatics, biomathematics, and computer science. To stay competitive in these new arenas, leading universities must develop new organizational strategies for assembling research teams, keeping investigators current, and providing Core and infrastructure support. Rapid changes in basic science and computational methods, and the multidisciplinary nature of research, mandate such an approach. Vanderbilt proposes a Linked Knowledge Model as an organizational framework for creating an environment of excellence in biomedical information science and technology to maximize multidisciplinary research. Elements of this model: 1) on-going development of trans-institutional strategy; 2) use of the resulting vision to coordinate recruitment and incorporate intellectual capital into flexible problem solving teams; 3) adoption of modular education programs to move new knowledge rapidly across boundaries, serving both neophytes and established investigators; and, 4) creation of centers of excellence combining a traditional support Core with research into next generation techniques, tool development and education. Vanderbilt's BISTI planning project will test and refine the elements of the Linked Knowledge organization model. It will showcase prototypic multidisciplinary scientific projects that produce new informatics and computational research and tools to address challenging biological problems. It will position Vanderbilt to establish a full-scale national program of excellence in biomedical computing. Organizational lessons, tools/techniques, and biologic findings will be broadly applicable beyond Vanderbilt.

描述（由申请人提供）：范德比尔特大学定位于在基因组学和蛋白质组学领域取得引人注目的科学进步-将创新的计算方法与基础生物科学的进步相结合。新的定量技术和工具的不断涌现将使功能生物学取得进展；这个流依赖于信息学、生物数学和计算机科学的研究结果。为了在这些新领域保持竞争力，一流大学必须制定新的组织战略，以组建研究团队，使研究人员保持最新状态，并提供核心和基础设施支持。基础科学和计算方法的快速变化，以及研究的多学科性质，要求采用这种方法。范德比尔特提出了一个关联知识模型，作为创建生物医学信息科学和技术卓越环境的组织框架，以最大限度地开展多学科研究。该模式的要素：1)跨机构战略的持续发展；2)利用由此产生的愿景来协调招聘，并将智力资本纳入灵活的问题解决团队；3)采用模块化教育方案，快速跨界传播新知识，为新手和资深研究者服务；4)创建将传统支持核心与下一代技术、工具开发和教育研究相结合的卓越中心。范德比尔特大学的BISTI规划项目将测试和完善关联知识组织模型的要素。它将展示多学科科学项目的原型，这些项目将产生新的信息学和计算研究以及解决具有挑战性的生物学问题的工具。它将使范德比尔特大学在生物医学计算领域建立一个全面的国家卓越项目。组织课程、工具/技术和生物学发现将广泛适用于范德比尔特以外的地方。