CENTER FOR RESEARCH ON CARDIOVASCULAR AND RESPIRATORY HE

申请人：（申请人？摘要）心脏疾病， 脑血管疾病和慢性阻塞性肺疾病排名1，3 在美国，死亡原因分别为4种和4种。的总体目的 心血管和呼吸健康研究中心（CRCRH） 促进心血管和呼吸系统健康科学，减少 通过提供核心服务， 为调查人员提供服务和资源。CRCRCRH的工作将是 通过三个研究核心完成：（a）多族裔重点核心，（B） 生物行为方法核心和（c）发展传播核心。CRCRH将 赞助研究，以促进心血管和呼吸系统的科学 在第一年，将资助三名新手调查员， 开展试点研究，一项是呼吸系统健康，两项是心血管健康。的 CRCRH的科学是由健康相关的生活质量组织的， 框架.这一框架的关键要素包括人（个人）因素， 环境因素，生理心理变量，症状 状态、功能状态、总体健康感知和生活质量。 CRCRCRH支持的研究将（a）减少差距，促进健康 心血管和呼吸系统健康的生活方式，（B）阐明潜在的 导致症状的生理和心理机制， 功能状态、自觉健康状态和生活质量，（c）测试 干预措施，以尽量减少症状，提高功能状态，自觉健康 生活状况和质量。CRCRCRH支持的研究将（a） 强烈的生物行为取向和（B）跨越性别和所有年龄 组此外，CRCRRH还将重点促进 多民族研究和通过研究减少健康差距。的 心血管和呼吸系统健康研究相结合 由于科学领域尚未出现重叠，单一中心的优势 被探索。来自两个地区的调查人员的互动将推动 科学朝着新的方向发展。

DESCRIPTION: (from applicant?s Abstract) Diseases of the heart, cerebrovascular diseases and chronic obstructive pulmonary diseases rank 1, 3 and 4 respectively as causes of death in the US. The overall purpose of the Center for Research on Cardiovascular and Respiratory Health (CRCRH) is to advance the science of cardiovascular and respiratory health, reduce disparities in disease/illness and support research training by providing core services and resources to investigators. The work of the CRCRH will be accomplished through three research cores (a) Multi-ethnic Emphasis Core, (b) Biobehavior Methods Core and (c) Development Dissemination Core. The CRCRH will sponsor research to advance the science in cardiovascular and respiratory health and in the first year three novice investigators will be funded to conduct pilot studies, one in respiratory and two in cardiovascular health. The science of the CRCRH is organized by a health-related quality of life framework. Key elements in this framework include person (individual) factors, environmental factors, physiological and psychological variables, symptom status, functional status, general health perception, and quality of life. Studies supported by the CRCRH will (a) reduce disparity and promote healthy life styles for cardiovascular and respiratory health, (b) elucidate underlying physiological and psychological mechanisms that contribute to symptoms, functional status, perceived health status and quality of life, (c) test interventions to minimize symptoms, enhance functional status, perceived health status and quality of life. The research supported by the CRCRH will (a) have a strong biobehavioral orientation and (b) cut across both genders and all age groups. In addition the CRCRH will have a strong emphasis on facilitating multi-ethnic research and reducing disparity in health through research. The combining of cardiovascular and respiratory health research under the umbrella of a single center is a strength due to overlaps in the science that have not been explored. The interaction of investigators from both areas will move the science forward in new directions.