MRI OF CORONARY ARTERIES USING HYPERPOLARIZED HELIUM

使用超极化氦进行冠状动脉 MRI

• 批准号: 6493716
• 负责人: MARK S CHAWLA
• 金额: $ 28.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6493716
• 关键词: Mammalia; biomedical equipment development; biomedical resource; human tissue; nuclear magnetic resonance spectroscopy; technology /technique

This project will try various schemes to optimize the contrast of gray/white matter in the rat brain at 2T. Several pulse sequences will be used: projection, 3D ir-prepped gradient echo and 3D gradient echo, as well as FSE. A variety of flip angles and TI values will be tried for the gradient echo sequences motivated by results at 1.5T. T1, T2 and proton density will be measured in 3 rats in various brain regions such as CP (caudate-putamen), cortical gray, colliculum and corpus callosum. This will allow calculation of optimum contrast sequences. Under the assumption that the rat brain contains mostly 'gray matter', the necessary resolution to satisfactorily resolve the thin boundaries provided by white matter tracts and fluid regions will be investigated.

本项目将尝试各种方案，优化对比度， 在2 T下大鼠脑中的灰/白色物质。 多脉冲序列 将使用：投影、3D红外准备梯度回波和3D梯度 echo和FSE。 各种翻转角和TI值将被 在1.5T下的结果激励下尝试梯度回波序列。 将在3只大鼠的不同脑中测量T1、T2和质子密度 区域如CP（尾状核-壳核）、皮质灰质、丘和 胼胝体 这将允许计算最佳对比度 序列的 假设老鼠的大脑中 “灰色问题”，必要的决议，以圆满解决 由白色物质束和流体区域提供的薄边界将 追究