VASCULAR MR IMAG USING HYPERPOLARIZ 3HE DUAL WALLED MICROSPHERES: ANGIOGRAPHY

使用 HYPERPOLARIZ 3HE 双壁微球的血管 MR 成像：血管造影

• 批准号: 6220707
• 负责人: MARK S CHAWLA
• 金额: $ 3万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220707
• 关键词: Mammalia; biomedical resource; human tissue; model design /development; nuclear magnetic resonance spectroscopy; respiratory system; technology /technique

The elastase model of emphysema in the guinea pig results in pathology resembling panacinar emphysema seen in frequently humans. We propose to use both proton and helium MRI to follow, in vivo, the development of emphysema in this model from the earliest to the latest stages of the disease. Proton imaging will allow us to define the interstitial changes and hyperpolarized helium will provide data on the expected changes in the distal air spaces. We will combine these structural analyses with assessments of pulmonary function to clarify the physiologic interpretation of the MR images.

豚鼠肺气肿的弹性蛋白酶模型导致 病理学类似于常见于人类的全腺泡肺气肿。 我们建议使用质子和氦MRI来跟踪体内的 该模型中肺气肿从最早到最晚的发展 疾病的阶段。 质子成像将使我们能够确定 间隙变化和超极化氦将提供数据， 远端空气空间的预期变化。 我们将联合收割机 结构分析和肺功能评估，以阐明 MR图像的生理解释。