Anti-fungal garlic-derived polysulfides:- Modes of action and applications in food crop protection (HAMILTON_U17ICASE)

抗真菌大蒜衍生多硫化物：- 作用方式及其在粮食作物保护中的应用 (HAMILTON_U17ICASE)

• 批准号: 1941038
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1941038
• 关键词: Anti; fungal; garlic; derived; polysulfides

Prompted by environmental and health concerns associated with many chemical pesticides there is now an urgent need for alternative pest control methods in food crop protection programs.Garlic extracts display broad spectrum activity against numerous food crop pests, offering appealing pest control alternatives, which are biodegradable and pose less risk to humans and animal welfare. The most prominent bioactive components in garlic extracts are a series of unusual organosulfur molecules known as diallyl-polysulfides (DAPS). Preliminary studies indicate that once DAPS enter the target pathogen their bioactivity can be triggered by reaction with thiol cofactors such as glutathione to perturb the intracellular redox status and ultimately cause cell death. In collaboration with ECOspray (http://www.ecospray.com/) this project aims to:1. Unravel how DAPS induce oxidative stress in fungal pathogens at the biochemical level.2. Reveal how this correlates with their effects different stages of the fungal life cycle3. Use this information, in field trial settings, to optimise DAPS treatment regimens to protect numerous food crops (eg. Potato, pea, tomato) against fungal pests.

由于与许多化学农药相关的环境和健康问题，现在迫切需要在粮食作物保护计划中寻找替代害虫防治方法。大蒜提取物对多种粮食作物害虫表现出广谱活性，提供了有吸引力的害虫防治替代品，这些替代品可生物降解，对人类和动物福利构成的风险较小。大蒜提取物中最突出的生物活性成分是一系列不寻常的有机硫分子，称为二烯丙基多硫化物（DAPS）。初步研究表明，一旦DAPS进入目标病原体，其生物活性可以通过与谷胱甘肽等硫醇辅助因子的反应来触发，扰乱细胞内的氧化还原状态，最终导致细胞死亡。与 ECOspray (http://www.ecospray.com/) 合作，该项目旨在：1。揭示DAPS如何在生化水平上诱导真菌病原体氧化应激。2．揭示这与它们在真菌生命周期不同阶段的影响之间的关系3。在田间试验环境中使用这些信息来优化 DAPS 处理方案，以保护多种粮食作物（例如马铃薯、豌豆、番茄）免受真菌害虫的侵害。