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Developing novel synthetic biology tools for next generation biologics and biomaterial manufacturing

开发用于下一代生物制品和生物材料制造的新型合成生物学工具

基本信息

批准号：
1941228
负责人：
金额：
--
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2021
资助国家：
英国
起止时间：
2021 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1941228
关键词：
Developing novel synthetic biology tools

项目摘要

The recent advances in synthetic biology have now enabled us to generate new tools for producing customised protein-based biologics or biomaterials by unlocking the potential of non-natural living materials. In this project, we will develop new genetic and protein based tools and technologies to control the production of large, difficult-to-express or toxic proteins/enzymes in microbial cell factories with an aim of increased yields and improved quality. These proteins generally possess important therapeutic or bio-catalytic functions and thus are of high economical and societal value. In addition, we will develop and apply these scale tools to produce tunable biomaterials with customised mechanical or optical functionalities that could have either military or wide civil usage. For instance, protection biomaterials may be engineered which is resistant to strong mechano stretch yet still extremely light and transparent.The project will provide the student a comprehensive training of advanced molecular cloning and genetic tools, innovative synthetic biology techniques, microbiology and biochemistry skills. The research thus gives the student an inter-disciplinary research experience and cutting edge technologies exposure to prepare well for his/her future research career. The student may also benefit from the opportunity to work collaboratively with some of our industrial partners in biotechnology and biomedicine.

合成生物学的最新进展现在使我们能够通过释放非天然生物材料的潜力来生产定制的基于蛋白质的生物制剂或生物材料的新工具。在这个项目中，我们将开发新的基于遗传和蛋白质的工具和技术，以控制微生物细胞工厂中大的、难以表达的或有毒的蛋白质/酶的生产，目的是提高产量和质量。这些蛋白质通常具有重要的治疗或生物催化功能，因此具有很高的经济和社会价值。此外，我们将开发和应用这些规模工具来生产可调谐的生物材料，这些材料具有定制的机械或光学功能，可以用于军事或广泛的民用。例如，保护生物材料可以设计成既能抵抗强烈的机械拉伸，又能非常轻和透明。该项目将为学生提供先进的分子克隆和遗传工具、创新的合成生物学技术、微生物学和生物化学技能的全面培训。因此，该研究为学生提供了跨学科的研究经验和尖端技术的接触，为他/她未来的研究生涯做好准备。学生还将有机会与我们在生物技术和生物医学方面的一些工业合作伙伴合作。