Elastic fibre-matrix interactions important for tissue development, morphology and function

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The properties of many tissues are controlled by the type, ratio and organisation of structural proteins laid down into extracellular matrices. Molecular interactions between these different proteins are essential for normal tissue strength, form and function. We are investigating the interactions of protein components of elastic fibres, with structural molecules of the surrounding matrix including collagens, proteoglycans and basement membrane components. At present our knowledge of these interactions is limited even though they are essential for anchorage during stretching of elastic fibres in compliant tissues such as arterial walls, lung and skin. In addition several of the elastic fibre-associated proteins appear to be important in the matrix of non-elastic tissues such as bone and cornea. The project will continue to increase our fundamental understanding of the normal development and function of different connective tissues. This knowledge will, in turn, lead to much greater elucidation of the mechanisms leading to a) loss of tissue function in major disease processes such as atherosclerosis, blood vessel aneurysms, pulmonary emphysema and UV-induced skin damage, and b) developmental abnormalities in congenital disorders such as Marfan syndrome and a variety of corneal dystrophies.