Conte Centers for the Neuroscience of Depression

孔特抑郁症神经科学中心

• 批准号: 6528592
• 负责人: RANGA R KRISHNAN
• 金额: $ 239.27万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528592
• 关键词: behavioral /social science research tag; depression; neurosciences

DESCRIPTION OF OVERALL CENTER (provided by applicant): The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. We will use the naturally occurring lesions in the elderly depressed as a model. We will use a lesion approach to study the mood circuit and affect regulation. A total of 5 projects are proposed. The first examines localization of lesions, structural changes in critical regions subserving the circuit and alterations in the white matter tracts relevant to the circuit. The second project uses post mortem cell counting and glial volume assessment to assess changes in the relevant region. The third project uses cognitive paradigms and functional MRI to probe the circuit. The fourth project uses transgenic and knockout mice to examine the role of norepinephrine and serotonin as it relates to the circuit. The final project is designed to assess in humans the impact of norepinephrine and serotonin depletion in remitted depressed patients with lesions to evaluate the importance of these neurotransmitters as a mechanism. Three shared resources, administrative, research, and assessment and data management/statistics are proposed to facilitate the conduct of these projects and to ensure integration at the conceptual, analytical and patient availability level, and flow to the various projects. Findings from the center should greatly enhance our understanding of the biology of depressive disorders, but may also be of help in improving the treatment of these disorders. In addition, the technological innovations developed in the context of this project are likely to be of major importance and relevant to other studies of brain function.

总体中心描述（由申请人提供）：拟议的 Silvio O. 孔特抑郁症神经科学中心将重点了解 抑郁症的神经生物学机制。我们将利用自然发生的 以老年人抑郁症病变为典范。我们将使用病变方法 研究情绪回路并影响调节。共有5个项目 建议的。第一个检查病变的定位、结构变化 维护回路和白质变化的关键区域 与电路相关的小册子。第二个项目使用死后细胞 计数和神经胶质体积评估以评估相关区域的变化。 第三个项目使用认知范式和功能性 MRI 来探讨 电路。第四个项目使用转基因和基因敲除小鼠来检查 去甲肾上腺素和血清素的作用与电路有关。决赛 该项目旨在评估去甲肾上腺素和去甲肾上腺素对人类的影响 对患有病变的抑郁症缓解患者进行血清素消耗评估 这些神经递质作为一种机制的重要性。三个共享资源， 行政、研究和评估以及数据管理/统计 提议促进这些项目的开展并确保整合 在概念、分析和患者可用性层面，并流向 各种项目。该中心的调查结果应该会极大地提高我们的 了解抑郁症的生物学，但也可能有帮助 改善这些疾病的治疗。此外，技术 在该项目背景下开发的创新可能具有重大意义 重要性以及与其他脑功能研究的相关性。