Human Imaging

人体成像

• 批准号: 7478384
• 负责人: RANGA R KRISHNAN
• 金额: $ 33.58万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7478384
• 关键词: Amygdaloid structure; Anterior; Arts; Brain; Cognitive; Corpus striatum structure; Diffusion Magnetic Resonance Imaging; Fiber; Genetic Variation; Genetic screening method; Glutamates; Human; Image; Lead; Lesion; Link; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mental Depression; Moods; Multimodal Imaging; Nature; Neurocognitive; Patients; Prefrontal Cortex; Promoter Regions; Structure; Work; base; follow-up; image processing; older patient; serotonin transporter

This project is central to the Conte center. All other projects are linked to this project in a conceptual and a practical sense. This project follows up on our findings that lesions disrupt the functioning of the mood circuit in elderly patients with depression. The project utilizes multimodal imaging Diffusion tensor imaging (DTI), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) along with cognitive testing and genetics to study the connectivity and dysregulation of the mood circuit. Based on findings from our earlier work we evaluate the nature of the changes in the fiber tracts connecting amygdala, Orbital prefrontal cortex, dorsolateral prefrontal cortex, striatum and its relationship to neurocognitive changes. We evaluate whether glutamate is reduced in the anterior cingulate and orbital prefrontal cortex in patients with depression using MRS. In addition we evaluate changes in brain structure and function as it relates to serotonin transporter promoter region allelic variants. This project uses state of the art image processing and will lead to a greater understanding of the neuroanatomical substrates of depression.

这个项目是孔蒂中心的中心。所有其他项目都链接到此项目的 以及一种实用的感觉。该项目对我们的发现进行了跟进，即损伤会扰乱大脑的功能 老年抑郁症患者的情绪回路。该项目利用多模式成像扩散 张量成像(DTI)、磁共振成像(MRI)、磁共振波谱(MRS) 与认知测试和遗传学一起研究情绪的连通性和失调 巡回赛。根据我们早期工作的发现，我们评估了纤维变化的性质 连接杏仁核、眶前额叶皮质、背外侧前额叶皮质、纹状体及其 与神经认知变化的关系。我们评估谷氨酸是否 用磁共振波谱研究抑郁症患者的前扣带回和眶前额叶皮质的减少 此外，我们还评估了与5-羟色胺转运体有关的大脑结构和功能的变化。 启动子区域等位基因变异。该项目使用最先进的图像处理技术，将导致 对抑郁症的神经解剖学基础有更多的了解。