ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING

习惯学习期间大鼠纹状体的整体活动

• 批准号: 6528587
• 负责人: Ann M Graybiel
• 金额: $ 24.38万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-03 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528587
• 关键词: behavior prediction; behavioral habituation /sensitization; brain electrical activity; corpus striatum; habits; hippocampus; histology; laboratory rat; learning; neural information processing; neurophysiology; neuropsychological tests; neuropsychology; reinforcer

DESCRIPTION:(adapted from applicant's abstract) In this proposal, it is hypothesized that during the development of habit learning, ensemble activity of striatal neurons undergoes systematic changes. It is proposed to test this hypothesis by using multiple tetrode chronic recording methods to record activity of striatal neurons during learning in rats, and by performing a set of analyses to characterize single-unit and ensemble activity in relation to task acquisition and performance. They propose to determine the factors responsible for changes in striatal activity during procedural learning in a t-maze, and to determine whether different striatal zones and corticostriatal loops undergo different patterns of plasticity during learning. They will also compare the response patterns in the striatum and hippocampus during acquisition of the cued "win-stay" versus memory based "win-shift" versions of the task. They will test the following hypotheses: (1) The large response to the go-signal that they have found to develop over learning is hypothesized to reflect a general readiness to respond rather than a response to detailed reward prediction or instructed behavior prediction. (2) The large changes that they have found to occur in turning responses are hypothesized to reflect the development of habit, and will not occur in the win-shift task. (3) They hypothesize that learning related changes will be selective for, and different in, the dorsolateral and medial caudoputamen and that these changes will be different from those in the corresponding cortical areas. (4) They hypothesize that during win-stay and win-shift t-maze learning, the dorsolateral caudoputamen and the hippocampus will code different classes of information, whereas the medial caudoputamen and the hippocampus will process similar information in different manners. They propose to test these hypotheses by using different versions of the t-maze task to vary predictability of reward or instructed behavior, to vary win-stay versus win-shift task requirements, by recording in different striatal sites and in pairs of striatal and cortical sites making up functionally distinct corticostriatal loops, and by comparing striatal and hippocampal neuronal activities during training on the win-stay and win-shift t-maze tasks.

描述：（改编自申请人摘要） 在这个建议中，假设在习惯的发展过程中， 学习，纹状体神经元的整体活动经历了系统的变化。 建议通过使用多个四极管慢性 记录方法记录纹状体神经元在学习过程中的活动， 大鼠，并通过进行一组分析来表征单单位和 集体活动与任务获取和执行有关。他们提出 以确定纹状体活动变化的因素， 在t-迷宫中的程序学习，并确定是否不同的纹状体 区和皮质纹状体回路经历不同的可塑性模式， 学习他们还将比较纹状体的反应模式， 海马体在获得线索“赢-留”与基于记忆 任务的“双赢”版本。他们将测试以下假设：（1） 他们发现，对前进信号的巨大反应， 学习被假设为反映了一种普遍的反应准备，而不是 对详细的奖励预测或指示的行为预测的响应。（二） 他们发现，在转向反应中发生的巨大变化是 假设反映了习惯的发展，不会发生在 胜利轮班任务(3)他们假设与学习相关的变化将是 选择性的，不同的，背外侧和内侧尾壳， 这些变化将不同于相应的皮质 地区(4)他们假设在赢-留和赢-移的t-迷宫学习中， 背外侧尾壳核和海马体将编码不同的类别 信息，而内侧尾壳核和海马体将 以不同的方式处理类似的信息。他们建议测试这些 假设通过使用不同版本的T-迷宫任务， 奖励或指示行为的可预测性，以改变赢留与 Win-Shift任务要求，通过记录不同的纹状体部位和 成对的纹状体和皮质部位构成功能上不同的 皮质纹状体回路，并通过比较纹状体和海马神经元 活动在训练期间的赢-停留和赢-转移的T-迷宫任务。