ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING

描述：(改编自申请者摘要) 在这个建议中，它假设在习惯的发展过程中 学习、纹状体神经元的整体活动经历了系统性的变化。 建议通过使用多个四极管慢性测试来检验这一假设 记录大鼠学习期间纹状体神经元活动的记录方法 并通过执行一组分析来表征单个单元和 与任务习得和绩效相关的整体活动。他们提议 确定导致纹状体活动变化的因素 在T型迷宫中进行程序性学习，并确定不同纹状体 带和皮质纹状体环经历了不同的可塑性模式 学习。他们还将比较纹状体和 海马体在获得线索“赢-留”与基于记忆的过程中 这项任务的“双赢”版本。他们将检验以下假设：(1) 他们发现对GO信号的巨大反应已经结束 学习被假设为反映了一种普遍的反应准备，而不是 对详细的奖励预测或指导行为预测的响应。(2) 他们发现，在转变反应过程中发生的巨大变化是 假设反映了习惯的养成，而不会发生在 双赢转移任务。(3)他们假设与学习相关的变化将是 选择性和不同的背外侧尾壳核和内侧尾壳核和 这些变化将不同于相应的大脑皮层 区域。(4)他们假设在赢-留和赢-移T-迷宫学习过程中， 背外侧尾壳核和海马体将编码不同的类别 而内侧尾壳核和海马体 以不同的方式处理相似的信息。他们建议对这些进行测试 假设通过使用不同版本的T型迷宫任务来改变 奖励或指导行为的可预测性，以不同的赢-留与 Win-Shift任务要求，通过在不同的纹状体位置和在 成对的纹状体和皮质部位在功能上是截然不同的 皮质纹状体环，并通过比较纹状体和海马神经元 训练期间的双赢-停留和双赢-移位T形迷宫任务。

DESCRIPTION:(adapted from applicant's abstract) In this proposal, it is hypothesized that during the development of habit learning, ensemble activity of striatal neurons undergoes systematic changes. It is proposed to test this hypothesis by using multiple tetrode chronic recording methods to record activity of striatal neurons during learning in rats, and by performing a set of analyses to characterize single-unit and ensemble activity in relation to task acquisition and performance. They propose to determine the factors responsible for changes in striatal activity during procedural learning in a t-maze, and to determine whether different striatal zones and corticostriatal loops undergo different patterns of plasticity during learning. They will also compare the response patterns in the striatum and hippocampus during acquisition of the cued "win-stay" versus memory based "win-shift" versions of the task. They will test the following hypotheses: (1) The large response to the go-signal that they have found to develop over learning is hypothesized to reflect a general readiness to respond rather than a response to detailed reward prediction or instructed behavior prediction. (2) The large changes that they have found to occur in turning responses are hypothesized to reflect the development of habit, and will not occur in the win-shift task. (3) They hypothesize that learning related changes will be selective for, and different in, the dorsolateral and medial caudoputamen and that these changes will be different from those in the corresponding cortical areas. (4) They hypothesize that during win-stay and win-shift t-maze learning, the dorsolateral caudoputamen and the hippocampus will code different classes of information, whereas the medial caudoputamen and the hippocampus will process similar information in different manners. They propose to test these hypotheses by using different versions of the t-maze task to vary predictability of reward or instructed behavior, to vary win-stay versus win-shift task requirements, by recording in different striatal sites and in pairs of striatal and cortical sites making up functionally distinct corticostriatal loops, and by comparing striatal and hippocampal neuronal activities during training on the win-stay and win-shift t-maze tasks.