课题基金 / 基金详情

ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING

ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING
习惯学习期间大鼠纹状体的整体活动
批准号:
6647028
负责人:
Ann M Graybiel
金额:
$24.36万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-08-03 至 2005-07-31

项目摘要

项目成果

Ann M Graybiel的其他基金

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中文摘要
翻译
描述:(改编自申请人的摘要) 在这个提议中,假设在习惯的养成过程中 在学习过程中,纹状体神经元的整体活动发生系统性变化。 建议通过使用多个四极慢性 记录学习过程中纹状体神经元活动的记录方法 大鼠,并通过进行一组分析来表征单个单元和 与任务获取和执行相关的整体活动。他们提议 确定导致纹状体活动变化的因素 t 迷宫中的程序学习,并确定不同的纹状体是否 区域和皮质纹状体环在过程中经历不同的可塑性模式 学习。他们还将比较纹状体的反应模式和 海马体在获得提示的“胜利停留”与基于记忆的过程中 任务的“win-shift”版本。他们将检验以下假设:(1) 他们发现对开始信号的巨大反应 假设学习反映了普遍的反应准备状态,而不是 对详细奖励预测或指导行为预测的反应。 (2) 他们发现转弯反应中发生的巨大变化是 假设反映了习惯的发展,并且不会发生在 双赢任务。 (3) 他们假设与学习相关的变化将是 对背外侧和内侧尾壳核有选择性且不同 这些变化将不同于相应皮质的变化 地区。 (4) 他们假设在 win-stay 和 win-shift t 迷宫学习过程中, 背外侧尾壳核和海马体将编码不同的类别 信息,而内侧尾壳核和海马体将 以不同的方式处理相似的信息。他们建议测试这些 通过使用不同版本的 t 迷宫任务来改变假设 奖励或指导行为的可预测性,以改变获胜与停留 win-shift 任务要求,通过记录不同的纹状体部位和 成对的纹状体和皮质位点构成功能不同的 皮质纹状体环,并通过比较纹状体和海马神经元 在 win-stay 和 win-shift t 迷宫任务训练期间进行的活动。
英文摘要
DESCRIPTION:(adapted from applicant's abstract) In this proposal, it is hypothesized that during the development of habit learning, ensemble activity of striatal neurons undergoes systematic changes. It is proposed to test this hypothesis by using multiple tetrode chronic recording methods to record activity of striatal neurons during learning in rats, and by performing a set of analyses to characterize single-unit and ensemble activity in relation to task acquisition and performance. They propose to determine the factors responsible for changes in striatal activity during procedural learning in a t-maze, and to determine whether different striatal zones and corticostriatal loops undergo different patterns of plasticity during learning. They will also compare the response patterns in the striatum and hippocampus during acquisition of the cued "win-stay" versus memory based "win-shift" versions of the task. They will test the following hypotheses: (1) The large response to the go-signal that they have found to develop over learning is hypothesized to reflect a general readiness to respond rather than a response to detailed reward prediction or instructed behavior prediction. (2) The large changes that they have found to occur in turning responses are hypothesized to reflect the development of habit, and will not occur in the win-shift task. (3) They hypothesize that learning related changes will be selective for, and different in, the dorsolateral and medial caudoputamen and that these changes will be different from those in the corresponding cortical areas. (4) They hypothesize that during win-stay and win-shift t-maze learning, the dorsolateral caudoputamen and the hippocampus will code different classes of information, whereas the medial caudoputamen and the hippocampus will process similar information in different manners. They propose to test these hypotheses by using different versions of the t-maze task to vary predictability of reward or instructed behavior, to vary win-stay versus win-shift task requirements, by recording in different striatal sites and in pairs of striatal and cortical sites making up functionally distinct corticostriatal loops, and by comparing striatal and hippocampal neuronal activities during training on the win-stay and win-shift t-maze tasks.
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会议论文
Project 3_Graybiel : Circuit-Specific Disruption, Pharmacological, and Neurophysiological Studies of Approach/Avoidance Behaviors in Mice and Non-Human Primates
  • 批准号:
    10383687
  • 项目类别:
  • 资助金额:
    $60.57万
  • 财政年份:
    2020
  • 负责人:
    Ann M Graybiel
  • 依托单位:
Project 3_Graybiel : Circuit-Specific Disruption, Pharmacological, and Neurophysiological Studies of Approach/Avoidance Behaviors in Mice and Non-Human Primates
  • 批准号:
    10601137
  • 项目类别:
  • 资助金额:
    $60.24万
  • 财政年份:
    2020
  • 负责人:
    Ann M Graybiel
  • 依托单位:
Consequences of Synucleinopathy and Dopamine Depletion
  • 批准号:
    6842098
  • 项目类别:
  • 资助金额:
    $21.0万
  • 财政年份:
    2004
  • 负责人:
    Ann M Graybiel
  • 依托单位:
Functional and anatomical characterization of the striosomal system