EFFECT OF DEPRESSIVE EMOTIONS ON AIRWAYS IN ASTHMA

抑郁情绪对哮喘气道的影响

• 批准号: 6538846
• 负责人: BRUCE D MILLER
• 金额: $ 38.15万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6538846
• 关键词: adolescence (12-20); asthma; autonomic nervous system; autonomic reflex; behavioral /social science research tag; clinical research; cortisol; depression; human subject; neuroendocrine system; neuroregulation; respiratory airway volume

DESCRIPTION (Adapted from the Applicant's Abstract): The objective of the proposed project is to apply a unique conceptual model and laboratory, method, developed by the P.I., to investigate conditions under which, and mechanisms by which, depressive emotional states affect autonomic processes associated with airways function in asthma. This objective will be accomplished by further testing and elaborating the Autonomic (ANS) Dysregulation Model of Emotional Influence on Asthma (Miller 1987, Miller & Wood, 1997) which proposes that depressed, despairing or hopeless emotional states are associated with ANS dysregulation such that a cholinergic (PNS) bias potentiates cholinergically (PNS) mediated airways constriction! giving rise to a psychophysiologically vulnerable asthmatic state. The movie "E.T., the Extra-Terrestrial" will be used to provide emotion-specific challenges to 138 male and 138 female adolescents, ages 11-16 (Tanner stages 2-5), with asthma, while continuously measuring autonomic nervous system (ANS) modulation of the cardio-respiratory system and airway function. Scenes evoking fear, sadness/hopelessness, happiness/excitement and mixed sadness/happiness will be compared to each other and to a neutral scene and baseline. Salivary cortisol and airway function (FEV1) measures will be taken pre and post movie and after each scene. Oxygen saturation will be measured throughout the movie. Subjects' asthma and emotional state will be profiled before the movie. Airway reactivity will be measured by methacholine challenge test (PC20). Hopeless/depressed states will be assessed by the Hopelessness Scale for Children and the Child Depression Inventory, adjusted for anxiety. Autonomic (SNS and PNS) reactivity is reflected by heart rate responses to experimentally induced emotional challenge, i. e., the "movie". Two convergent methods Will he used differentiate sympathetic (SNS) from parasympathetic (PNS) modulation of the cardio-respiratory system: 1) impedance cardiography (PEP) for SNS, respiratory sin us arrhythmia (RSA) for PNS; 2) and Power Spectral Analysis (PSA) of heart rate variability (HRV), which yields indices of SNS and PNS. Hypothesized relationships between PC20, hopeless/depressed states, PNS and SNS activation, cortisol and airways function will be tested. Multiple regression and repeated measures analysis of variance methods will be used to analyze the data. Medication effects will be assessed and analyses covaried if necessary.

描述（根据申请人的摘要改编）： 拟议的项目是应用独特的概念模型和实验室方法，方法， 由P.I.开发的，以调查条件，并通过该条件 抑郁情绪状态会影响与 气道在哮喘中起作用。这个目标将通过进一步完成 测试和阐述情绪的自主（ANS）失调模型 对哮喘的影响（Miller 1987，Miller＆Wood，1997年），提出了 沮丧，绝望或绝望的情绪状态与ANS相关 失调使胆碱能（PNS）偏向胆碱能增强 （PNS）介导的气道收缩！从心理生理产生 脆弱的哮喘状态。 电影“ E.T.，外星人”将用于提供 对138名男性和138名女性青少年的情感特定挑战，年龄在11-16岁 （坦纳阶段2-5），哮喘，同时不断测量自主神经 神经系统（ANS）对心脏呼吸系统和气道的调节 功能。场景引起恐惧，悲伤/绝望，幸福/兴奋和 混合的悲伤/幸福将彼此比较，并与中立的场景进行比较 和基线。唾液皮质醇和气道功能（FEV1）措施将是 拍摄前电影和后的每个场景之后。氧饱和度将是 在整部电影中测量。受试者的哮喘和情绪状态将是 在电影之前进行了剖析。气道反应性将通过甲基苯胺测量 挑战测试（PC20）。绝望/沮丧状态将由 儿童的绝望量表和儿童抑郁量表，调整后 焦虑。自主神经（SNS和PNS）反应性反映了心率 对实验引起的情感挑战的反应，即。例如，“电影”。 他将使用两种收敛方法，他将使用区分交感神（SNS）与 心脏呼吸系统的副交感神经（PNS）调节：1）阻抗 SNS的心脏摄影（PEP），PNS的呼吸道犯罪美国心律不齐（RSA）； 2）和 心率变异性（HRV）的功率谱分析（PSA），该分析产生 SNS和PNS的索引。 PC20，绝望/抑郁状态，PN和SNS之间的假设关系 将测试激活，皮质醇和气道功能。多重回归 并重复测量方差方法分析将用于分析 数据。在必要时，将评估药物效应并分析协方差。