CLINICAL AND ADMINISTRATIVE

临床和管理

• 批准号: 7676829
• 负责人: BRUCE D MILLER
• 金额: $ 56.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7676829
• 关键词: Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Autopsy; Biological; Biostatistics Core; Blood specimen; Clinical; Clinical Data; Communication; Communities; Congresses; Consent; Data; Data Quality; Dementia; Emotions; Enrollment; Ensure; Evaluation; Frontotemporal Dementia; Funding; Genetic; Human; Image; Individual; Measures; Monitor; Neurologic; Neurology; Neuropsychology; Paralysed; Pathology; Patients; Personality; Policies; Population; Procedures; Progressive Supranuclear Palsy; Publications; Range; Receptive aphasia; Recording of previous events; Recruitment Activity; Regulation; Research Infrastructure; Resources; Sampling; Semantic Dementias; Standards of Weights and Measures; Strategic Planning; Testing; Tissues; United States National Institutes of Health; Vertebral column; brain behavior; clinical Diagnosis; cohort; corticobasal degeneration; data management; neurobehavior; neurobehavioral; neuropsychological; programs; quality assurance; research clinical testing; social; symposium

The Clinical and Administrative Core provides essential operational functions for the entire PPG. This Core will recruit patients with frontotemporal dementia (FTD), semantic dementia (SD), progressive non-fluent aphasia (PNFA), progressive supranuclear palsy (PSP), corticobasaldegeneration (CBD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and normal control subjects. Each subject will receive a comprehensive evaluation measuring a broad range of neurological, neuropsychological,functional, neurobehavioral, and social-personality variables. In addition, subjects will be followed annually to collect longitudinal data and maintain high enrollment in our autopsy program. Administrative functions of this Core include the infrastructure for establishing policies and procedures, maintaining communication within the PPG and between the PPG and the scientific community, ensuring optimal utilization and monitoring of PPG resources, and ensuring the scientific and ethical integrity of all PPG practices. Once recruited into the Clinical and Administrative Core, subjects will be referred to Projects 2 (Imaging; Dr. Weiner), 3 (Emotion; Dr. Levenson), 4 (Clinical Diagnosis; Dr. Miller), and 5 (Brain-Behavior; Dr. Rosen). In addition, blood samples will be sent to the Genetics Core (Dr.Geschwind) and autopsy tissue will be sent to the Pathology Core (Drs. Trojanowski and Lee). The Clinical and Administrative Core will also interact extensively with the Data Management and Biostatistics Core (Dr.Fox) for data management, data quality, and data analysis functions.

临床和行政核心为整个PPG提供了必不可少的操作功能。这个核心 会招募额颞痴呆（FTD），语义痴呆（SD）的患者，进行性非浮力 失语症（PNFA），进行性核上麻痹（PSP），皮质巴替型过渡（CBD），肌萎缩症 侧硬化症（ALS），阿尔茨海默氏病（AD）和正常对照受试者。每个主题都会收到一个 综合评估衡量广泛的神经，神经心理学，功能， 神经行为和社会人格变量。此外，每年将遵循主题以收集 纵向数据并维持我们的尸检计划的高度入学率。该核心的管理功能 包括用于制定政策和程序的基础架构，维持在内部的沟通 PPG以及PPG与科学界之间，确保PPG的最佳利用和监测 资源，并确保所有PPG实践的科学和道德完整性。一旦招募到 临床和行政核心，受试者将转介给项目2（成像； Weiner博士），第3（情感； Levenson博士），4（临床诊断； Miller博士）和5（脑行为； Rosen博士）。另外，血液 样品将被发送到遗传学核心（Dr.Geschwind），尸检组织将被发送到病理学 核心（Trojanowski和Lee博士）。临床和行政核心也将与 用于数据管理，数据质量和数据分析的数据管理和生物统计学核心（DR.FOX） 功能。