CLINICAL AND ADMINISTRATIVE

临床和行政核心为整个PPG提供基本的业务职能。此核心 将招募额颞性痴呆(FTD)、语义性痴呆(SD)、进行性不流利的患者 失语症(PNFA)、进行性核上性瘫痪(PSP)、皮质基底膜变性(CBD)、肌营养不良 侧索硬化症(ALS)、阿尔茨海默病(AD)和正常对照组。每名受试者将收到一份 综合评估测量了广泛的神经学、神经心理学、功能、 神经行为和社会人格变量。此外，受试者每年将被跟踪收集 纵向数据，并在我们的尸检计划中保持高注册人数。这一核心的管理职能 包括用于建立政策和程序、在 PPG以及PPG与科学界之间的合作，确保PPG的最佳利用和监测 资源，并确保所有PPG实践的科学和道德完整性。一旦被招募到 临床和行政核心，受试者将被转介到项目2(成像；韦纳博士)，3(情绪； Levenson博士)、4(临床诊断；Miller博士)和5(大脑行为；Rosen博士)。此外，血液 样本将被送往遗传学核心(Geschind博士)，尸检组织将被送往病理学 Core(Dr.Trojanowski和Lee)。临床和行政核心还将与 数据管理和生物统计核心(Dr.Fox)，用于数据管理、数据质量和数据分析 功能。

The Clinical and Administrative Core provides essential operational functions for the entire PPG. This Core will recruit patients with frontotemporal dementia (FTD), semantic dementia (SD), progressive non-fluent aphasia (PNFA), progressive supranuclear palsy (PSP), corticobasaldegeneration (CBD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and normal control subjects. Each subject will receive a comprehensive evaluation measuring a broad range of neurological, neuropsychological,functional, neurobehavioral, and social-personality variables. In addition, subjects will be followed annually to collect longitudinal data and maintain high enrollment in our autopsy program. Administrative functions of this Core include the infrastructure for establishing policies and procedures, maintaining communication within the PPG and between the PPG and the scientific community, ensuring optimal utilization and monitoring of PPG resources, and ensuring the scientific and ethical integrity of all PPG practices. Once recruited into the Clinical and Administrative Core, subjects will be referred to Projects 2 (Imaging; Dr. Weiner), 3 (Emotion; Dr. Levenson), 4 (Clinical Diagnosis; Dr. Miller), and 5 (Brain-Behavior; Dr. Rosen). In addition, blood samples will be sent to the Genetics Core (Dr.Geschwind) and autopsy tissue will be sent to the Pathology Core (Drs. Trojanowski and Lee). The Clinical and Administrative Core will also interact extensively with the Data Management and Biostatistics Core (Dr.Fox) for data management, data quality, and data analysis functions.