Training in Mouse and Molecular Genetics of the Eye

描述（由申请人提供）：通过在分子水平上理解基因功能，生物医学科学已经发生了革命性的变化。实验室小鼠已经并将继续在阐明基因功能和参与正常发育和维持的途径以及视觉系统的病理学方面发挥关键作用。然而，很少有专门培训分子遗传学家使用小鼠模型进行视觉研究的项目。杰克逊实验室要求资助建立一个NEI博士后培训计划，重点是视觉研究中的小鼠和分子遗传学。TJL研究人员的七名成员组成了一个跨学科的实习导师库，他们正在使用经典和尖端的分子遗传学方法研究小鼠眼睛发育和遗传性眼病的各个方面。遗传学定义的动物模型的实验工作提供了机会，以测试有关疾病的遗传基础的假设，并模拟新的诊断和治疗方式。这些类型的分析是可能的实验室的特殊近交系，自发和诱导突变小鼠的无与伦比的资源基础的可用性。 这个新的NEI培训补助金要求在头两年和三年内提供两个博士后职位。受训人员将主要精力投入到实验室研究中，并融入TJL研讨会，课程，研讨会和研究兴趣小组。他们需要写研究金申请书，并每年在内部兴趣小组和国家或国际会议上提交研究结果。他们的进展由一个正式的培训委员会监督，每个委员会的成员都是几个受训者的非正式导师或联络人。完成培训后，参与者将有资格在大学，研究机构或行业中从事视觉科学的创造性，独立研究。 主要的培训设施是杰克逊实验室，一个私人的，独立的研究中心。TJL是美国国立卫生研究院基础癌症研究中心，自1956年以来一直在举办NIH研究培训赠款

DESCRIPTION (provided by applicant): Biomedical science has been revolutionized by understanding gene function at the molecular level. The laboratory mouse has and will continue to playa key role in elucidating gene function and pathways involved in normal development and maintenance, and pathology of the visual system. Yet there are few programs dedicated to training molecular geneticists in the use of mouse models for vision research. The Jackson Laboratory requests funding to establish a NEI postdoctoral training program focused on mouse and molecular genetics in vision research. Seven members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who are investigating various aspects of eye development and heritable ocular diseases in the mouse using classical and cutting edge molecular genetic approaches. Experimental work in genetically-defined animal models provides the opportunity to test hypotheses regarding the genetic basis of disorders and to model new diagnostic and therapeutic modalities. These types of analyses are made possible by the availability of the Laboratory's unparalleled resource base of special inbred, spontaneous and induced-mutant mice. This new NEI Training Grant requests two postdoctoral positions for the first two years and three, thereafter. Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops, and research interest groups. They are required to write fellowship applications, and present their results annually, both at in-house interest groups and national or international meetings. Their progress is overseen by a formal Training Committee, each member of which acts as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in vision sciences at a university, research institution, or in industry. The primary training facility is The Jackson Laboratory, a private, independent research center. TJL is a NIH Basic Cancer Research Center, and has held NIH research training grants continuously since 1956