Core--Aquatic Toxicology

核心--水生毒理学

• 批准号: 6443389
• 负责人: EVAN P GALLAGHER
• 金额: $ 13.16万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443389
• 关键词: animal colony; aquatic organism; biomedical facility; environmental toxicology; fish; hazardous substances; water pollution

The Aquatic Toxicology Core Facility provides technical expertise and facilities for the rearing, holding and toxicological testing of aquatic organisms. The aquatic core facility was completed in 1999 through funding from the University of Florida's College of Veterinary Medicine and Institute for Food and Agricultural Sciences, and currently operates on a cost-recovery basis. The incentive for establishment of the aquatic facility was based upon the extensive research efforts in aquatic toxicology form a number of University of Florida researchers and the lack of other aquatic toxicology facilities available. Accordingly, financial support for this core is essential for the successful completion of those projects which involving holding and toxicant dosing of aquatic animals, including project #1 (Drs. Denslow and Gallagher), project #2 (Drs. Schoeb and Gross), and project #6 (Drs. James and Kleinow). The specific aims of the core are 1) to provide Superfund investigators with technical assistance and consultation during all aquatic experiments involving the rearing, husbandry and dosing of aquatic organisms, and 2) to provide a physical environment for carrying out aquatic toxicological studies pertinent to the Superfund Program project grant. The aquatic core facility has the capability to house multiple aquatic species and to conduct acute and chronic studies. Project investigators will work with the aquatic core manager in the design and execution of all in vivo aquatic studies. A maximum amount of flexibility has been designed into the facility, allowing the facilities to be adapted to an investigator's needs. The facility is supplied with dechlorinated city water at a maximum rate of 20,000 gpm and three-1hp regenerative blowers at a maximum rate of 70 cfm supply aeration throughout the facility. All effluent is removed via a central drain system. Included as a service of the facility is an evaluation of the investigator's protocols by the ATD advisory board. This board approves projects to be conducted with in the facility and makes suggestions concerning animal husbandry and effluent discharge. The facility also has trained staff to perform water quality analysis and disease diagnosis and treatment.

水生毒理学核心设施为水生生物的饲养、保存和毒理学测试提供技术专门知识和设施。水生核心设施是在佛罗里达大学兽医学院和食品和农业科学研究所的资助下于1999年建成的，目前在成本回收的基础上运作。建立水生设施的动机是基于佛罗里达大学研究人员在水生毒理学方面的广泛研究工作，以及缺乏其他可用的水生毒理学设施。因此，对这一核心的财政支持对于成功完成涉及水生动物饲养和有毒剂量的项目至关重要，包括项目1（Denslow和Gallagher博士）、项目2（Schoeb和Gross博士）和项目6（James和Kleinow博士）。核心的具体目标是：1）在涉及水生生物的饲养，饲养和给药的所有水生实验期间为超级基金调查人员提供技术援助和咨询，以及2）为开展与超级基金项目赠款有关的水生毒理学研究提供物理环境。水生核心设施有能力容纳多种水生物种，并进行急性和慢性研究。项目研究人员将与水生核心经理合作设计和执行所有体内水生研究。该设施的设计具有最大限度的灵活性，使其能够适应调查员的需要。该设施供应的是最大速率为20，000 gpm的脱氯城市水和三台最大速率为70 cfm的1hp再生鼓风机，整个设施供应曝气。所有的污水都通过中央排水系统排出。该设施的一项服务是由扶贫国际运动咨询委员会对调查员的方案进行评价。该委员会批准在该设施内进行的项目，并就畜牧业和污水排放提出建议。该设施还拥有经过培训的工作人员，以进行水质分析和疾病诊断和治疗。