Bipolar Disorder Genetics: An Affected Sib Pair Family S

双相情感障碍遗传学：受影响的同胞对家庭 S

• 批准号: 6546827
• 负责人: DENNIS L MURPHY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6546827
• 关键词: behavioral /social science research tag; behavioral genetics; bipolar depression; clinical research; disease /disorder proneness /risk; family genetics; gene expression; genetic susceptibility; human subject; siblings

The long-term goal of the project is the identification of genes that contribute to the overall genetic risk in bipolar disorder and the characterization of the biological function of these genes. It is anticipated that improvements in treatment, diagnosis and possibly prevention will evolve once genetic contributions to affective disorders are established. At present, the NIMH-IRP site is functioning primarily to collect additional affected bipolar sib pairs to enlarge the overall sample available to the NIMH grant-funded Bipolar Genetics consortium. In the past year, the NIMH-IRP site enrolled 27 BP families and completed interviews and submitted blood samples on 25 affected sibling pairs plus 51 family members. Other families are in varying stages of completing the protocol requirements. The completion of the first genome scan on multiplex families with bipolar affective disorder by our consortium provided evidence for susceptibility regions on 13q32, 1q32 and 18p11.2. Additional findings were published recently. Interestingly, some of these regions overlap with proposed chromosomal areas containing predisposing loci for schizophrenia. These results raise the possibility that schizophrenia and affective disorders share some susceptibility loci. Identifying candidate gene (genes localized in susceptibility regions) will require use of developing genetic technologies.

该项目的长期目标是鉴定导致双相情感障碍总体遗传风险的基因，并描述这些基因的生物学功能。一旦确定了情感障碍的遗传因素，预计治疗、诊断和可能的预防方面将有所改进。目前，NIMH-IRP网站的主要功能是收集更多受影响的双极同胞对，以扩大NIMH资助的双极遗传学联盟可用的总体样本。在过去的一年里，NIMH-IRP网站招募了27个BP家庭，完成了访谈，并提交了25个受影响的兄弟姐妹对和51个家庭成员的血液样本。其他家庭正处于完成方案要求的不同阶段。本研究组首次完成了双相情感障碍多重家系的基因组扫描，为13 q32、1 q32和18p11.2的易感区域提供了证据。最近发表了其他研究结果。有趣的是，其中一些区域与含有精神分裂症易感基因座的染色体区域重叠。这些结果提出了精神分裂症和情感障碍共享某些易感基因座的可能性。确定候选基因（位于易感区域的基因）将需要使用正在开发的遗传技术。