Bipolar Disorder Genetics: An Affected Sib Pair Family S

双相情感障碍（BP）是一种严重的遗传性疾病，约占人口的1%至2%。人们对遗传模式知之甚少，可能涉及多个影响中等的基因座。NIMH-IRP是参与一项多中心研究的12个站点之一，该研究集中于受影响的兄弟姐妹家庭，其总体目标是从BP家庭中收集适合连锁和关联研究的大量访谈样本和细胞系。整个项目由NIMH校外项目（MH 59535）资助。研究设计使用受影响的兄弟姐妹及其家庭成员。DNA和访谈数据被收集并在这个研究BP情感障碍的研究人员联盟中共享。根据NIMH的标准，细胞系和访谈数据最终将免费提供给科学界。

Bipolar (BP) affective disorder is a severe, heritable condition affecting about one to two percent of the population. The mode of inheritance is poorly understood and probably involves multiple loci of moderate effect. The NIMH-IRP is one of twelve sites participating in a multi-center study concentrating on affected sibling pair families with the overall aim of collecting a large sample of interviews and cell lines from BP families suitable for linkage and association studies. The overall project is funded by an NIMH Extramural Program (MH 59535) grant. The study design uses affected sibling pairs and their family members. DNA and interview data are collected and shared within this consortium of investigators studying BP affective disorder. Cell lines and interview data will eventually be made freely available to the scientific community according to NIMH criteria. The NIMH-IRP site has now enrolled and ascertained a total of over 2000 individuals consisting of BP sibling pairs and their families. (the second highest number among all of the twelve nationwide sites in the Consortium). The initial results from a whole genome screen analysis using the first half of the new data from 250 BP families collected since 1998 was published this year. Two chromosomal regions (one on 17q and one on 6q) had lod scores of 3.63 and 3.61 that met simulation criteria for genome-wide significance. Continuation of this protocol will allow expansion of a sample of affected sibling pairs and their family members. This should add to the likelihood of identifying chromosomal regions and genes relevant to BP and related neuropsychiatric disorders.