Epitranscriptomic mechanisms of endocrine signalling

内分泌信号的表观转录组机制

• 批准号: 1945091
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1945091
• 关键词: Epitranscriptomic; mechanisms; endocrine; signalling

Epitranscriptomics, dynamic covalent modifications of RNA, has recently emerged as an important determinant of gene expression, splicing and translation. The most abundant RNA modification, m6A, is catalysed by the METTL3 complex, whereas two enzymes, FTO and ALKBH5, are believed to be responsible for RNA demethylation. The focus of this project is to identify diverse functions of the epitranscriptome in endocrine signalling.

表观转录组学是RNA的动态共价修饰，近年来已成为基因表达、剪接和翻译的重要决定因素。最丰富的RNA修饰，m6A，是由METTL3复合体催化的，而两种酶，FTO和ALKBH5，被认为负责RNA去甲基化。这个项目的重点是确定表位转录组在内分泌信号中的不同功能。

项目成果

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.

• DOI: 10.3389/fendo.2022.1006101
• 发表时间: 2022
• 期刊: FRONTIERS IN ENDOCRINOLOGY
• 影响因子: 5.2
• 作者: Harris, Anna E.;Metzler, Veronika M.;Lothion-Roy, Jennifer;Varun, Dhruvika;Woodcock, Corinne L.;Haigh, Daisy B.;Endeley, Chantelle;Haque, Maria;Toss, Michael S.;Alsaleem, Mansour;Persson, Jenny L.;Gudas, Lorraine J.;Rakha, Emad;Robinson, Brian D.;Khani, Francesca;Martin, Laura M.;Moyer, Jenna E.;Brownlie, Juliette;Madhusudan, Srinivasan;Allegrucci, Cinzia;James, Victoria H.;Rutland, Catrin S.;Fray, Rupert G.;Ntekim, Atara;de Brot, Simone;Mongan, Nigel P.;Jeyapalan, Jennie N.
• 通讯作者: Jeyapalan, Jennie N.

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

• DOI: 10.3390/cancers14205148
• 发表时间: 2022-10-20
• 期刊: Cancers
• 影响因子: 5.2