Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across Adolescence

早期生活压力与青春期抑郁之间关联的心理生物学机制

• 批准号: 10749429
• 负责人: IAN H GOTLIB
• 金额: $ 75.37万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749429
• 关键词: 13 year old; 9 year old; Address; Adolescence; Adolescent; Adult; Adverse effects; Affect; Age; Air Pollutants; Award; Behavior assessment; Behavioral; Biological; Biological Aging; Blood; Brain; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 pandemic effects; Cause of Death; Child; Childhood; Clinical; Cognitive; Cohort Studies; Collaborations; Complement; Data; Data Analytics; Data Set; Development; Diagnosis; Dimensions; Disease; Endocrine; Environmental Exposure; Environmental Pollutants; Equation; Exposure to; Family; Grant; Health; Immunologics; Interview; Life; Life Cycle Stages; Machine Learning; Measurement; Measures; Mental Depression; Mental Health; Modeling; Not Hispanic or Latino; Outcome; Paper; Parents; Participant; Persons; Physiology; Predictive Factor; Prevention; Prevention program; Prospective Studies; Psychopathology; Publishing; Quarantine; Rewards; Risk; Risk Factors; Saliva; Sampling; Series; Severities; Singapore; Specimen; Stress; Stressful Event; Suicide attempt; Symptoms; Techniques; Testing; United States National Institutes of Health; Work; Youth; boys; cohort; coronavirus disease; deprivation; early life adversity; early life stress; economic disparity; experience; girls; health disparity populations; high risk; large datasets; longitudinal dataset; neural; neurodevelopment; neuroimaging; pandemic disease; prenatal; promote resilience; psychobiologic; psychosocial; public health relevance; racial population; recruit; resilience; resilience factor; risk prediction; southeast Asian; stress reactivity; suicidal behavior; treatment program; young adult

Abstract More than 50% of youth will experience at least one form of significant adversity in early life. Such adversities pose significant risk not only for the development of psychopathology over the life course, but also for attempted suicide, a leading cause of death in people ages 10-24 years. We have recruited and assessed 220 9- to 13-year-old boys and girls across four timepoints, each two years apart, to examine the effects of exposure to ELS on trajectories of stress reactivity and reward sensitivity, and, in turn, their impact on the onset of psychopathology and suicidal behaviors across adolescence. In this cohort we have conducted repeated measurements of symptoms and diagnoses of psychopathology, neural, endocrine, cognitive, immunological, and behavioral assessments of stress reactivity and reward sensitivity, and early exposure to adversity, including the type, severity, and timing of stressful events. We have published a series of papers from this project elucidating the effects of ELS on psychobiological functioning, trajectories of brain development, and biological aging, and the consequences of these alterations for clinical functioning. In this MERIT renewal application, we propose to build on and extend our work in three important ways. First, we will conduct an additional assessment of our participants at age 20 in order to examine the effects of ELS on trajectories of neurodevelopment and clinical outcomes from childhood to young adulthood, as well as the persistence of COVID-19 pandemic-related difficulties in mental health, stress, and brain metrics. We will also extend our examination of how environmental pollutants and conditions affect relations among these variables. Second, we will extend and replicate our findings in a younger, non-Western sample by analyzing data from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) project, an ongoing prospective study in which many of the same, or comparable, measures that we administered in our project have also been collected regularly from approximately 1,500 parents and children since the prenatal period. Extending and replicating our findings with the GUSTO dataset, which includes younger, non-Western children from Southeast Asian families in Singapore, will complement findings from other large cohorts, like ABCD and NCANDA, that have assessed only Western participants. Finally, will leverage our own and GUSTO data to examine the effects of the COVID-19 pandemic shutdown on children’s and adolescents’ psychobiological functioning. In both datasets we have a unique opportunity to compare comprehensive psychobiological data collected from the same youth before and after the pandemic shutdowns in order not only to examine how the pandemic has altered young people’s psychobiological functioning and development, but importantly, to also identify risk and resilience factors across cultural contexts. Further, the new proposed adult assessment in our ELS project will allow us to examine the persistence of COVID-related difficulties by re-assessing participants whom we studied soon after pandemic quarantine restrictions ended.

摘要 超过50%的年轻人在早期生活中至少会经历一种形式的重大逆境。等 逆境不仅对生命历程中精神病理学的发展构成重大风险，而且 自杀未遂是10-24岁人群死亡的主要原因。我们招募并评估了 220名9至13岁的男孩和女孩在四个时间点，每隔两年，检查的影响， 暴露于ELS对压力反应和奖励敏感性的轨迹，以及反过来，它们对 在青春期出现精神病理学和自杀行为。在这个队列中，我们进行了 反复测量症状和精神病理学、神经、内分泌、认知、 免疫学和行为评估的压力反应性和奖励敏感性，以及早期暴露于 逆境，包括压力事件的类型，严重程度和时间。我们发表了一系列论文 从这个项目阐明ELS对心理生物学功能的影响， 发育和生物老化，以及这些改变对临床功能的后果。在这 MERIT续期申请，我们建议在三个重要方面建立和扩展我们的工作。一是 对20岁的参与者进行额外评估，以研究ELS对 从儿童到青年的神经发育和临床结果的轨迹，以及 在心理健康、压力和大脑指标方面持续存在与COVID-19大流行相关的困难。我们还将 扩展我们的研究如何环境污染物和条件影响这些变量之间的关系。 第二，我们将通过分析来自美国的数据，在一个年轻的非西方样本中扩展和复制我们的发现。 “在新加坡健康成长”（GUSTO）项目是一项正在进行的前瞻性研究， 我们在项目中管理的许多相同或类似的措施也是如此。 自产前以来，定期从大约1 500名父母和儿童那里收集数据。延伸和 用GUSTO数据集复制我们的发现，该数据集包括年龄较小的非西方儿童， 新加坡的东南亚家庭，将补充其他大型队列的发现，如ABCD和 NCANDA只评估了西方参与者。最后，将利用我们自己和GUSTO的数据， 研究COVID-19大流行对儿童和青少年心理生物学的影响 功能在这两个数据集中，我们有一个独特的机会来比较全面的心理生物学数据 在大流行停止之前和之后从同一个年轻人那里收集的数据，不仅为了研究 大流行改变了年轻人的心理生物学功能和发展，但重要的是， 确定跨文化背景的风险和复原力因素。此外，我们建议的新成人评估 ELS项目将使我们能够通过重新评估参与者来检查COVID相关困难的持续性 在大流行隔离限制结束后不久，我们对他们进行了研究。