Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across Adolescence

早期生活压力与青春期抑郁之间关联的心理生物学机制

• 批准号: 10749429
• 负责人: IAN H GOTLIB
• 金额: $ 75.37万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749429
• 关键词: 13 year old; 9 year old; Address; Adolescence; Adolescent; Adult; Adverse effects; Affect; Age; Air Pollutants; Award; Behavior assessment; Behavioral; Biological; Biological Aging; Blood; Brain; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 pandemic effects; Cause of Death; Child; Childhood; Clinical; Cognitive; Cohort Studies; Collaborations; Complement; Data; Data Analytics; Data Set; Development; Diagnosis; Dimensions; Disease; Endocrine; Environmental Exposure; Environmental Pollutants; Equation; Exposure to; Family; Grant; Health; Immunologics; Interview; Life; Life Cycle Stages; Machine Learning; Measurement; Measures; Mental Depression; Mental Health; Modeling; Not Hispanic or Latino; Outcome; Paper; Parents; Participant; Persons; Physiology; Predictive Factor; Prevention; Prevention program; Prospective Studies; Psychopathology; Publishing; Quarantine; Rewards; Risk; Risk Factors; Saliva; Sampling; Series; Severities; Singapore; Specimen; Stress; Stressful Event; Suicide attempt; Symptoms; Techniques; Testing; United States National Institutes of Health; Work; Youth; boys; cohort; coronavirus disease; deprivation; early life adversity; early life stress; economic disparity; experience; girls; health disparity populations; high risk; large datasets; longitudinal dataset; neural; neurodevelopment; neuroimaging; pandemic disease; prenatal; promote resilience; psychobiologic; psychosocial; public health relevance; racial population; recruit; resilience; resilience factor; risk prediction; southeast Asian; stress reactivity; suicidal behavior; treatment program; young adult

Abstract More than 50% of youth will experience at least one form of significant adversity in early life. Such adversities pose significant risk not only for the development of psychopathology over the life course, but also for attempted suicide, a leading cause of death in people ages 10-24 years. We have recruited and assessed 220 9- to 13-year-old boys and girls across four timepoints, each two years apart, to examine the effects of exposure to ELS on trajectories of stress reactivity and reward sensitivity, and, in turn, their impact on the onset of psychopathology and suicidal behaviors across adolescence. In this cohort we have conducted repeated measurements of symptoms and diagnoses of psychopathology, neural, endocrine, cognitive, immunological, and behavioral assessments of stress reactivity and reward sensitivity, and early exposure to adversity, including the type, severity, and timing of stressful events. We have published a series of papers from this project elucidating the effects of ELS on psychobiological functioning, trajectories of brain development, and biological aging, and the consequences of these alterations for clinical functioning. In this MERIT renewal application, we propose to build on and extend our work in three important ways. First, we will conduct an additional assessment of our participants at age 20 in order to examine the effects of ELS on trajectories of neurodevelopment and clinical outcomes from childhood to young adulthood, as well as the persistence of COVID-19 pandemic-related difficulties in mental health, stress, and brain metrics. We will also extend our examination of how environmental pollutants and conditions affect relations among these variables. Second, we will extend and replicate our findings in a younger, non-Western sample by analyzing data from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) project, an ongoing prospective study in which many of the same, or comparable, measures that we administered in our project have also been collected regularly from approximately 1,500 parents and children since the prenatal period. Extending and replicating our findings with the GUSTO dataset, which includes younger, non-Western children from Southeast Asian families in Singapore, will complement findings from other large cohorts, like ABCD and NCANDA, that have assessed only Western participants. Finally, will leverage our own and GUSTO data to examine the effects of the COVID-19 pandemic shutdown on children’s and adolescents’ psychobiological functioning. In both datasets we have a unique opportunity to compare comprehensive psychobiological data collected from the same youth before and after the pandemic shutdowns in order not only to examine how the pandemic has altered young people’s psychobiological functioning and development, but importantly, to also identify risk and resilience factors across cultural contexts. Further, the new proposed adult assessment in our ELS project will allow us to examine the persistence of COVID-related difficulties by re-assessing participants whom we studied soon after pandemic quarantine restrictions ended.

摘要 超过50%的年轻人会在早年经历至少一种形式的重大逆境。是这样的 逆境不仅对精神病理学在一生中的发展构成重大风险，而且 自杀未遂，这是10-24岁人群的主要死因。我们已经招募和评估了 220名9至13岁的男孩和女孩，跨越四个时间点，每个时间点相隔两年，以检查 暴露于ELS对应激反应和奖赏敏感性的影响，进而影响 青春期精神病理学和自杀行为的发病。在这个队列中，我们进行了 反复测量精神病理学、神经、内分泌、认知、 应激反应和奖励敏感性的免疫学和行为学评估，以及早期暴露于 逆境，包括压力事件的类型、严重性和时机。我们发表了一系列论文 从这个项目中阐明ELS对心理生物功能、大脑轨迹的影响 发育、生物老化以及这些变化对临床功能的影响。在这 为了满足续期申请的要求，我们建议在三个重要方面加强和扩展我们的工作。首先，我们将 在20岁时对我们的参与者进行额外的评估，以检查ELS对 从童年到成年的神经发育和临床结果的轨迹，以及 持续存在与新冠肺炎大流行相关的心理健康、压力和大脑指标方面的困难。我们还将 扩展我们对环境污染物和条件如何影响这些变量之间的关系的研究。 其次，我们将通过分析以下数据，在更年轻的非西方样本中扩展和复制我们的发现 在新加坡成长走向健康结果(GUSTO)项目，一项正在进行的前瞻性研究 我们在项目中管理的许多相同或类似的措施也是 自产前以来，定期从大约1,500名父母和儿童那里收集数据。扩展和 使用Gusto数据集复制我们的发现，其中包括来自 在新加坡的东南亚家庭，将补充来自其他大型队列的发现，如ABCD和 NCANDA只对西方参与者进行了评估。最后，将利用我们自己和感兴趣的数据来 检查新冠肺炎大流行关闭对儿童和青少年心理生物学的影响 功能正常。在这两个数据集中，我们有一个独特的机会来比较全面的心理生物学数据 从大流行关闭前后的同一批年轻人中收集数据，以便不仅检查 流行病改变了年轻人的心理生物功能和发育，但重要的是， 确定跨文化背景的风险和复原力因素。此外，本署新建议的成人评税 ELS项目将允许我们通过重新评估参与者来检查与COVID相关的困难的持久性 在大流行隔离限制结束后不久，我们对他进行了研究。