Vegf (in Situ Macular Edema & Uveitis

Vegf（原位黄斑水肿

• 批准号: 6507390
• 负责人: ROBERT B. NUSSENBLATT
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6507390
• 关键词: angiogenesis; blood; clinical research; diabetic retinopathy; edema; human tissue; immunopathology; plasma; protein biosynthesis; retina disorder; tocopherols; uveitis; vascular endothelial growth factors

Inreased intraocular and systemic levels of the angiogenic factor vascular endothelial growth factor (VEGF) is associated with new vessel growth in the eye, such as diabetic retinopathy. Recent work using immunopathologic techniques have shown that VEGF is upregulated in both experimentally induced uveitis and in uveitis eyes as well, with no evidence of neovascularization. This pilot study evaluated the level of VEGF in the blood of uveitic patients with and without cystoid macular edema. This level was determined also in the ocular fluid of those patietns undergoing ocular surgery. We measured the VEGF concentration in the aqueous humor of 20 uveitis patients (9 with and 11 without CME), and in the plasma of 40 uveitis patients (20 with and 20 without CME) and 20 healthy volunteers. Results: Mean aqueous humor VEGF concentrations for uveitis patients with and without CME were 152.3 and 109.5 pg/mL, p=0.048. Mean plasma VEGF concentrations in uveitis patients with and without CME and in healthy volunteers were 32.2, 29.6, and 55.0 pg/mL. Uveitis patients had lower plasma VEGF levels than healthy volunteers, p=0.002. Conclusions: VEGF concentration is elevated in the aqueous humor of uveitis patients with CME. Plasma VEGF concentration is reduced in uveitis patients on systemic immunosuppression. The VEGF antagonist Vitamin E will be investigated for the treatment of uveitis-associated CME.

血管生成因子血管内皮生长因子 (VEGF) 的眼内和全身水平升高与眼内新血管生长相关，例如糖尿病性视网膜病变。最近使用免疫病理学技术的研究表明，VEGF 在实验诱发的葡萄膜炎和眼葡萄膜炎中均上调，但没有新生血管形成的证据。该初步研究评估了患有或不患有黄斑囊样水肿的葡萄膜炎患者血液中 VEGF 的水平。还在接受眼科手术的患者的眼液中测定了该水平。我们测量了 20 名葡萄膜炎患者（9 名患有 CME 和 11 名不患有 CME）的房水中的 VEGF 浓度，以及 40 名葡萄膜炎患者（20 名患有 CME 和 20 名没有 CME）和 20 名健康志愿者的血浆中的 VEGF 浓度。结果：伴有和不伴有 CME 的葡萄膜炎患者的平均房水 VEGF 浓度分别为 152.3 和 109.5 pg/mL，p=0.048。患有和不患有 CME 的葡萄膜炎患者以及健康志愿者的平均血浆 VEGF 浓度分别为 32.2、29.6 和 55.0 pg/mL。葡萄膜炎患者的血浆 VEGF 水平低于健康志愿者，p=0.002。结论：合并CME的葡萄膜炎患者房水中VEGF浓度升高。接受全身免疫抑制的葡萄膜炎患者血浆 VEGF 浓度降低。 VEGF 拮抗剂维生素 E 将被研究用于治疗葡萄膜炎相关的 CME。