Perking up the Suzuki reaction with Co-Fe

用 Co-Fe 促进铃木反应

• 批准号: 1945257
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1945257
• 关键词: Perking; up; Suzuki; reaction; Co

The Suzuki reaction is a powerful tool for the production of new carbon-carbon bonds and is exploited industrially, for instance in the synthesis of intermediates for the sartan class of drugs for treating high blood pressure and in the production of agrochemical fungicides. Despite its high utility, the Suzuki reaction suffers from the need to use palladium-based catalysts. Palladium is expensive, relatively toxic and its extraction environmentally impacting. In this research, we will produce new classes of homogeneous catalysts based on the far cheaper, more benign and sustainable metal iron and cobalt. In particular we will focus on the development of catalysts that are capable of C(sp2)-C(sp2) bond-formation as these have proven to be particularly challenging to achieve with first row transition metal-based catalysts, yet are of particular interest to potential industrial end-users.

Suzuki反应是产生新的碳-碳键的有力工具，并在工业上得到利用，例如在用于治疗高血压的沙坦类药物的中间体的合成中以及在农业化学杀真菌剂的生产中。尽管铃木反应具有很高的实用性，但需要使用钯基催化剂。钯价格昂贵，毒性相对较大，并且其提取会对环境产生影响。在这项研究中，我们将生产基于更便宜，更良性和可持续的金属铁和钴的新型均相催化剂。特别地，我们将专注于能够形成C（sp2）-C（sp2）键的催化剂的开发，因为这些已经被证明是用第一行过渡金属基催化剂实现的特别具有挑战性的，但对潜在的工业终端用户特别感兴趣。

项目成果

Revisiting Claims of the Iron-, Cobalt-, Nickel-, and Copper-Catalyzed Suzuki Biaryl Cross-Coupling of Aryl Halides with Aryl Boronic Acids

重新审视铁、钴、镍和铜催化的芳基卤化物与芳基硼酸的铃木联芳基交叉偶联的主张

• DOI: 10.1021/acs.organomet.9b00083
• 发表时间: 2019
• 期刊: Organometallics
• 影响因子: 2.8
• 作者: Tailor S