Hybrid Bio-Nano Materials for Artificial Enzyme Design

化学策略被开发来设计天然的含辅因子的酶的模拟物，以使它们更稳健，但也探索活性增强和生物医学应用。为了实现这一点，修饰的多巴胺被合成为含有黄素或光点击官能团，以实现进一步的修饰。这样的多巴胺衍生物可以用于通过多巴胺聚合制备生物聚合物纳米颗粒或用于纳米颗粒（NP）涂层。后者对于能够设计其中铜或CeO2 NP通过外部诱导的活性氧物质的产生而充当活性催化中心的基于N的酶是特别令人感兴趣的。

Chemical strategies are developed to design mimics of natural, cofactor containing enzymes in order to make them more robust but also to explore the activity enhancement and biomedical applications. To achieve this, modified dopamine is synthesised either to contain flavin or photo-click functional groups to enable further modification. Such dopamine derivatives can either be used for preparation of biopolymeric nanoparticles through dopamine polymerisation or used for nanoparticle (NP) coating. The latter is particularly interesting to enable design of N- based enzymes in which copper or CeO2 NP act as active catalytic centres through externally induced production of reactive oxygen species.