Hybrid Bio-Nano Materials for Artificial Enzyme Design

用于人工酶设计的混合生物纳米材料

• 批准号: 1945802
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1945802
• 关键词: Hybrid; Bio; Nano; Materials; Artificial

Chemical strategies are developed to design mimics of natural, cofactor containing enzymes in order to make them more robust but also to explore the activity enhancement and biomedical applications. To achieve this, modified dopamine is synthesised either to contain flavin or photo-click functional groups to enable further modification. Such dopamine derivatives can either be used for preparation of biopolymeric nanoparticles through dopamine polymerisation or used for nanoparticle (NP) coating. The latter is particularly interesting to enable design of N- based enzymes in which copper or CeO2 NP act as active catalytic centres through externally induced production of reactive oxygen species.

人们开发了化学策略来设计含有辅因子的天然酶的模拟物，以使它们更加健壮，同时也探索了活性增强和生物医学应用。为了实现这一点，合成修饰的多巴胺以包含黄素或光点击官能团以实现进一步的修饰。这种多巴胺衍生物既可用于通过多巴胺聚合制备生物聚合物纳米颗粒，也可用于纳米颗粒(NP)包衣。后者特别有趣的是能够设计基于N的酶，其中铜或CeO2 NP通过外部诱导产生活性氧物种作为活性催化中心。

项目成果

Enzyme-inspired flavin-polydopamine as a biocompatible nanoparticle photocatalyst

• DOI: 10.1039/c9nh00199a
• 发表时间: 2019-11-01
• 期刊: NANOSCALE HORIZONS
• 影响因子: 9.7
• 作者: Crocker, Leander;Koehler, Philipp;Fruk, Ljiljana
• 通讯作者: Fruk, Ljiljana

Flavin-Conjugated Iron Oxide Nanoparticles as Enzyme-Inspired Photocatalysts for Azo Dye Degradation

• DOI: 10.3390/catal10030324
• 发表时间: 2020-03
• 期刊: Catalysts
• 影响因子: 3.9
• 作者: Samer I. Nehme;Leander Crocker;L. Fruk

Design and Application of Nanostructured Flavin Photocatalysts

纳米结构黄素光催化剂的设计与应用

• DOI: 10.17863/cam.62267
• 发表时间: 2020
• 作者: Crocker L