Elucidating the pathophysiological mechanisms leading to the development of hypertension late after repair of coarctation of the aorta: The key to decreasing premature death from hypertension after arch repair

阐明主动脉缩窄修复术后晚期高血压发生的病理生理机制：减少主动脉弓修复术后高血压过早死亡的关键

• 批准号: nhmrc : 1134274
• 负责人: Dr Melissa Lee
• 金额: $ 3.33万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-pathophysiological-mechanisms-arch-repair/948967
• 关键词: Elucidating; pathophysiological; mechanisms; leading; development

Coarctation of the aorta is a condition where there is a narrowing in the aorta (main blood vessel from the heart supplying blood to the body) and usually requires surgery early in life. Many may develop late hypertension (high blood pressure) after surgery, which is linked to early death. This research aims to establish the causes of this hypertension to ultimately determine how to best treat and prevent it to allow survivors of a coarctation repair a chance to live a full and healthy life.

主动脉缩窄是指主动脉（从心脏向身体供血的主要血管）变窄，通常需要在生命早期进行手术。许多人可能在手术后发展为晚期高血压（高血压），这与早期死亡有关。这项研究旨在确定这种高血压的原因，以最终确定如何最好地治疗和预防它，让缩窄修复术的幸存者有机会过上充实和健康的生活。