Elucidating the role of epididymosomes in the transfer of fertility-modulating proteins and regulatory classes of RNA to maturing spermatozoa

阐明附睾体在生育调节蛋白和 RNA 调节类别向成熟精子转移中的作用

• 批准号: nhmrc : 1147932
• 负责人: Dr Matthew Dun
• 金额: $ 35.97万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-role-epididymosomes-maturing-spermatozoa/1320949
• 关键词: Elucidating; role; epididymosomes; transfer; fertility

Sperm dysfunction represents a major underlying aetiology associated with male infertility. This proposal seeks to understand the mechanisms responsible for driving the functional maturation of spermatozoa and how these mechanisms are perturbed in response to environmental stressors.

精子功能障碍是男性不育的主要潜在病因。本研究旨在了解驱动精子功能成熟的机制，以及这些机制如何在环境压力下受到干扰。