Structural Studies of Pestivirus Envelope Glycoproteins

瘟病毒包膜糖蛋白的结构研究

• 批准号: 1947944
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1947944
• 关键词: Structural; Studies; Pestivirus; Envelope; Glycoproteins

Pestiviruses cause a wide range of symptoms from neural symptoms to loss of foetuses in utero or shortly after birth. This had a significant economic impact as the main animals affected by these viruses are livestock such as pigs, cows, and sheep. Currently the mechanism of cell entry is unknown and thought to be different from other viruses. Understanding the mechanism of cell entry could enable a targeted treatment as blocking cell entry would prevent infection. This project aims to investigate this entry mechanism through structural studies of the proteins known to be responsible for cell entry. These structural studies will be complimented by microscopy and biochemical experiments investigating how these proteins interact with each other.AfS, ENWW

瘟病毒引起广泛的症状，从神经症状到胎儿在子宫内或出生后不久死亡。这对经济产生了重大影响，因为受这些病毒影响的主要动物是猪、牛和羊等牲畜。目前，它进入细胞的机制尚不清楚，被认为与其他病毒不同。了解细胞进入的机制可以实现靶向治疗，因为阻断细胞进入可以防止感染。该项目旨在通过已知负责细胞进入的蛋白质的结构研究来研究这种进入机制。这些结构研究将通过显微镜和生物化学实验来补充，以研究这些蛋白质如何相互作用。