GENETIC CONTROL OF SKELETAL PATTERNING AND DEVELOPMENT
骨骼模式和发育的遗传控制
基本信息
- 批准号:6497446
- 负责人:
- 金额:$ 33.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-02-16 至 2005-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The vertebrate skeleton is almost entirely mesodermal in origin, aside from several bones in the skull which are derived from neural crest (Noden, 1992; Couly et al., 1993). In Drosophila one of the principal genes controlling mesoderm differentiation is the bagpipe homeobox gene (Azpiazu and Frasch, 1993; Azpiazu et al., 1996). We have previously isolated from mouse and human, homologues of bagpipe termed Bapx1. Examination of the expression of Bapx1 during embryogenesis revealed an expression almost exclusively restricted to paraxial and lateral plate mesoderm, with earliest expression detectable in the presclerotome cells of the somite (Tribioli et al., 1997; Tribioli and Lufkin, 1997). During subsequent stages of embryogenesis, Bapx1 is expressed in essentially all cartilaginous condensations which will subsequently undergo endochondral ossification. To investigate the role of Bapx1 in embryonic skeletogenesis, this proposal focuses primarily on loss-of-function (gene knockout) and gain-of-function studies in vitro and in vivo. Preliminary results from mice lacking Bapx1 indicate that it plays an essential role in chondroblast differentiation within the axial skeleton, which in turn leads to failed endochondral ossification.
除了头盖骨中的几块骨头来自神经嵴外,脊椎动物骨骼几乎完全是中胚层的(Noden, 1992; Couly et al., 1993)。在果蝇中,控制中胚层分化的主要基因之一是风管同源盒基因(Azpiazu and Frasch, 1993; Azpiazu et al., 1996)。我们之前已经从小鼠和人类中分离出了风笛的同源物,称为Bapx1。对Bapx1在胚胎发生期间表达的检测显示,Bapx1的表达几乎完全局限于近轴和侧板中胚层,最早的表达可在体体细胞前细胞中检测到(Tribioli et al., 1997; Tribioli and Lufkin, 1997)。在胚胎发生的后续阶段,Bapx1基本上在所有软骨凝聚体中表达,这些软骨凝聚体随后会发生软骨内成骨。为了研究Bapx1在胚胎骨骼形成中的作用,本研究主要关注体外和体内功能缺失(基因敲除)和功能获得的研究。来自缺乏Bapx1的小鼠的初步结果表明,它在轴向骨架内的成软骨分化中起重要作用,从而导致软骨内成骨失败。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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THOMAS LUFKIN其他文献
THOMAS LUFKIN的其他文献
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{{ truncateString('THOMAS LUFKIN', 18)}}的其他基金
Genome-Wide Analysis of the Transcriptional Cooperation Between Runx2 And Runx3 During Skeletal Development
骨骼发育过程中 Runx2 和 Runx3 之间转录合作的全基因组分析
- 批准号:
9812042 - 财政年份:2019
- 资助金额:
$ 33.24万 - 项目类别:
DIX5 HOMEOBOX GENE CONTROL OF CRANIOFACIAL MORPHOGENESIS
DIX5 同源盒基因控制颅面形态发生
- 批准号:
6651294 - 财政年份:2002
- 资助金额:
$ 33.24万 - 项目类别:
DIX5 HOMEOBOX GENE CONTROL OF CRANIOFACIAL MORPHOGENESIS
DIX5 同源盒基因控制颅面形态发生
- 批准号:
6617313 - 财政年份:2002
- 资助金额:
$ 33.24万 - 项目类别:
GENETIC CONTROL OF SKELETAL PATTERNING AND DEVELOPMENT
骨骼模式和发育的遗传控制
- 批准号:
6349973 - 财政年份:2000
- 资助金额:
$ 33.24万 - 项目类别:
DLX HOMEOBOX GENE CONTROL OF FETAL SKELETOGENESIS
胎儿骨骼形成的 DLX 同源框基因控制
- 批准号:
6634688 - 财政年份:2000
- 资助金额:
$ 33.24万 - 项目类别:
GENETIC CONTROL OF SKELETAL PATTERNING AND DEVELOPMENT
骨骼模式和发育的遗传控制
- 批准号:
6628128 - 财政年份:2000
- 资助金额:
$ 33.24万 - 项目类别:
DLX HOMEOBOX GENE CONTROL OF FETAL SKELETOGENESIS
胎儿骨骼形成的 DLX 同源框基因控制
- 批准号:
6719058 - 财政年份:2000
- 资助金额:
$ 33.24万 - 项目类别:
GENETIC CONTROL OF SKELETAL PATTERNING AND DEVELOPMENT
骨骼模式和发育的遗传控制
- 批准号:
6030056 - 财政年份:2000
- 资助金额:
$ 33.24万 - 项目类别:
DLX HOMEOBOX GENE CONTROL OF FETAL SKELETOGENESIS
胎儿骨骼形成的 DLX 同源框基因控制
- 批准号:
6379996 - 财政年份:2000
- 资助金额:
$ 33.24万 - 项目类别:
DLX HOMEOBOX GENE CONTROL OF FETAL SKELETOGENESIS
胎儿骨骼形成的 DLX 同源框基因控制
- 批准号:
6516614 - 财政年份:2000
- 资助金额:
$ 33.24万 - 项目类别:
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