Elucidation of the Genetic Mechanisms of Primary Aldosteronism: The Most Common, Curable Form of Hypertension

阐明原发性醛固酮增多症的遗传机制：最常见、可治愈的高血压形式

• 批准号: nhmrc : 1013597
• 负责人: Dr Amanda Rickard
• 金额: $ 22.29万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidation-genetic-mechanisms-form-hypertension/109731
• 关键词: Elucidation; Genetic; Mechanisms; Primary; Aldosteronism

Hypertension is a major cardiovascular risk factor that affects 10-40% of the population. The steroid hormone aldosterone controls blood pressure and plays a significant role in hypertension. Primary Aldosteronism (PAL), a condition caused by the excessive production of aldosterone, is the most common, curable form of hypertension. I will identify the molecular mechanisms responsible for PAL, to advance the development of new diagnostic tools and identification of novel therapeutic targets.

高血压是影响10-40%人口的主要心血管危险因素。类固醇激素醛固酮控制血压，在高血压中起着重要作用。原发性醛固酮增多症（PAL）是一种由醛固酮过量产生引起的疾病，是最常见的可治愈的高血压形式。我将确定负责PAL的分子机制，推进新的诊断工具的开发和新的治疗靶点的识别。