Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies
Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies
批准号:
19H01045
负责人:
Kira Jun-ichi
金额:
$29.37万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2019
资助国家:
日本
项目状态:
已结题
起止时间:
2019-04-01 至 2022-03-31
中文摘要
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英文摘要
期刊论文(44)
专著(0)
科研奖励(0)
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Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis
风险 HLA-DRB1 等位基因对日本多发性硬化症患者的大脑和病变体积有不同影响
DOI:
10.1016/j.jns.2020.116768
发表时间:
2020
期刊:
Journal of the Neurological Sciences
影响因子:
4.4
作者:
[Fukumoto S, Nakamura Y, Watanabe M, Isobe N, Matsushita T, Sakoda A, Hiwatashi A, Shinoda K, Yamasaki R, Tsujino A, Kira J.]
通讯作者:
Kira J.
Environmental risk factors for multiple sclerosis in Japanese people
日本人多发性硬化症的环境危险因素
DOI:
10.1016/j.msard.2019.101872
发表时间:
2020
期刊:
Multiple Sclerosis and Related Disorders
影响因子:
4
作者:
[Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Masaki K, Isobe N, Yamasaki R, Kira J.]
通讯作者:
Kira J.
LGI4 is a novel autoantigen for nodopathy/paranodopathy type chronic inflammatory demyelinating polyneuropathy
LGI4 是一种新型自身抗原,用于治疗结节病/偏向病型慢性炎症性脱髓鞘性多发性神经病
DOI:
--
发表时间:
2021
期刊:
影响因子:
--
作者:
[Xu Zhang, Hidenori Ogata, Tomohiro Imamura, Takayuki Fujii, Ryo Yamasaki, Jun-ichi Kira]
通讯作者:
Jun-ichi Kira
抗Plexin D1抗体による神経障害性疼痛と自律神経障害.
抗 Plexin D1 抗体引起的神经性疼痛和自主神经病变。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[田中 ひかり, 本間 秀典, 藤田 慶大, 近藤 和, Xiaocen Jin, 田川 一彦, 岡澤 均, Ohno H, Ohno H, 吉良潤一]
通讯作者:
吉良潤一
自己抗体陽性CIDP.
自身抗体 CIDP 阳性。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Hitoshi Okazawa, 緒方英紀]
通讯作者:
緒方英紀
共 35 条
A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression
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批准号:20K20470
-
项目类别:Grant-in-Aid for Challenging Research (Pioneering)
-
资助金额:$16.64万
-
财政年份:2019
-
负责人:Kira Jun-ichi
-
依托单位:
Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.
-
批准号:17K19663
-
项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$4.16万
-
财政年份:2017
-
负责人:Kira Jun-ichi
-
依托单位:
Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.
-
批准号:16H02657
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$30.28万
-
财政年份:2016
-
负责人:Kira Jun-ichi
-
依托单位:
Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.
-
批准号:15K15341
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:Kira Jun-ichi
-
依托单位:
connexin cytopathy in the pathogenesis of demyelinating disorders
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批准号:25293204
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2013
-
负责人:Kira Jun-ichi
-
依托单位:
海外基金