Investigation on friction between cardiovascular medical devices and arterial tissue

心血管医疗器械与动脉组织摩擦力的研究

• 批准号: 1949438
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1949438
• 关键词: Investigation; friction; between; cardiovascular; medical

Currently, very limited research has been carried out on the friction between cardiovascular medical devices such as stents and catheters and how arteries react to them. Also, little is known about the underlying friction mechanisms.This project is about generating reliable friction data in an in vitro environment. For this, endothelial cells (the cells covering the inside of arteries) will be cultured on a substrate and tribologically tested. Cell damage and reactions of the cells (deformation, gene expressions) will be investigated to find out how the cells react to the friction.Aims and Objectives:Determine friction coefficients between cardiovascular medical device materials and endothelial cells.Study the underlying friction mechanisms between endothelial cells and materials.Investigate the cells reactions to different materials under friction.Applications and benefits:Better understanding of cell-material interactions and friction mechanisms can be used to develop better materials and coatings.Improved simulations of medical devices can be carried out due to reliable friction data.This PhD project fits into the research area of Healthcare Technologies of the EPSRC.

目前，对心血管医疗器械（如支架和导管）之间的摩擦以及动脉如何对它们做出反应的研究非常有限。此外，对潜在的摩擦机制知之甚少。这个项目是关于在体外环境中产生可靠的摩擦数据。为此，将在基质上培养内皮细胞（覆盖动脉内部的细胞）并进行摩擦学测试。细胞损伤和细胞反应（变形、基因表达），以了解细胞对摩擦力的反应。目的和目的：测定心血管医疗器械材料与内皮细胞之间的摩擦系数。研究内皮细胞与材料之间的潜在摩擦机制。研究细胞对不同材料在摩擦下的反应。应用和益处：更好地理解细胞-材料相互作用和摩擦机制可用于开发更好的材料和涂层。由于可靠的摩擦数据。这个博士项目适合EPSRC的医疗保健技术的研究领域。