Phytotherapy of Prostateic Symptoms (POPW)

前列腺症状的植物疗法 (POPW)

• 批准号: 6587399
• 负责人: E DAVID CRAWFORD
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587399
• 关键词: aging; alternative medicine; benign prostate hyperplasia; chemotherapy; clinical research; cooperative study; disease /disorder prevention /control; ethnic group; human subject; human therapy evaluation; male; medicinal plants; method development; patient oriented research; plant extracts; urinary tract disorder

DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) are common in the aging male There are few well-designed, long term, multi-center, randomized clinical trials comparing the subjective and objective outcomes of physiotherapy of prostatic symptoms (POPS) AIM 1 To collaborate with a research consortium to design and conduct a multi-center randomized phase III clinical trial comparing saw palmetto, Pygeum africanum, or a placebo for treatment of symptomatic BPH AIM 2 To recruit and randomize 300 men (in two years) with symptomatic BPH who meet the protocol guidelines AIM 3 To design and implement a prospective randomized controlled trial for treatment of BPH that will determine which of the following predict successful treatment outcomes patient characteristics, AUA symptoms score, uroflow rate, and prostate size AIM 4 To design and implement recruitment interventions among racial and ethnic minority men and procedures for the maintenance of the long-term participation of study subjects.

描述（由申请人提供）： 提示良性前列腺梗阻（BPO）的下尿路症状（LUTS）在老年男性中很常见，但很少有设计良好的、长期的、多中心的、随机的临床试验比较物理治疗前列腺症状（POPS）的主观和客观结果 目的1与研究联盟合作，设计并进行一项多中心随机III期临床试验，比较锯棕榈、非洲臀果木或安慰剂治疗症状性前列腺增生的效果 目的2招募并随机选择300例符合方案指南的有症状的BPH患者（在两年内） 目的3设计并实施一项前列腺增生症治疗的前瞻性随机对照试验，以确定患者特征、AUA症状评分、尿流率和前列腺大小中哪些因素可预测成功的治疗结果 目的4设计和实施招募干预种族和少数民族的男性和程序，以保持长期参与的研究对象。