Phytotherapy of Prostateic Symptoms (POPW)

描述(由申请人提供)： 提示良性前列腺梗阻(BPO)的下尿路症状(LUT)在老年男性中很常见。很少有设计良好、长期、多中心、随机的临床试验比较前列腺症状理疗(POPS)的主客观结果。 目的1与一个研究联盟合作，设计并进行一项多中心、随机的III期临床试验，比较锯棕榈、非洲鬼臼或安慰剂治疗症状性良性前列腺增生症的疗效。 目标2招募300名符合方案指南的有症状的良性前列腺增生症患者并将其随机分组(两年内) 目的设计并实施一项用于治疗BPH的前瞻性随机对照试验，该试验将确定以下哪一项预测治疗结果：患者特征、AUA症状评分、尿流率和前列腺大小。 目的4设计和实施在种族和少数民族男子中的招募干预措施和维持研究对象长期参与的程序。

DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) are common in the aging male There are few well-designed, long term, multi-center, randomized clinical trials comparing the subjective and objective outcomes of physiotherapy of prostatic symptoms (POPS) AIM 1 To collaborate with a research consortium to design and conduct a multi-center randomized phase III clinical trial comparing saw palmetto, Pygeum africanum, or a placebo for treatment of symptomatic BPH AIM 2 To recruit and randomize 300 men (in two years) with symptomatic BPH who meet the protocol guidelines AIM 3 To design and implement a prospective randomized controlled trial for treatment of BPH that will determine which of the following predict successful treatment outcomes patient characteristics, AUA symptoms score, uroflow rate, and prostate size AIM 4 To design and implement recruitment interventions among racial and ethnic minority men and procedures for the maintenance of the long-term participation of study subjects.