Type 1 Diabetes TrialNet: Clinical Centers

描述（由申请人提供） 这是乔斯林儿童糖尿病中心的申请表s医院，a 目前的糖尿病预防试验-1（DPT-1）临床中心，成为一个 1型糖尿病国家糖尿病试验网络临床中心 Mellitus，TrialNet。TrialNet是一个全国性的临床合作网络， 研究小组将由临床中心和核心支持设施组成。 其共同目标将是进行干预研究，以预防、治疗或 改善人类1型糖尿病。TrialNet还将支持 在筛选或招募的人群中进行自然史和遗传学研究， 旨在更好地了解病因的特定研究， 1型糖尿病的发病机制，并制定策略，以防止 疾病 乔斯林糖尿病中心/儿童？s医院提出TrialNet临床 中心包括经验丰富的人员扩大资源，除了 * 扩大联系机构网络， 美国国立卫生研究院。我们的临床中心将有两个主要目标：1。完成 正在进行的DPT-1研究; 2.）参与设计和实施 现有的和未来的试点和扩大的研究，新的药物，以预防，治疗 或改善1型糖尿病，并参与和提供 遗传学和自然历史研究的资源。 正在进行的1型糖尿病预防试验（DPT-1）正在测试， 在非糖尿病患者中，早期肠外或口服胰岛素干预 1型糖尿病患者的亲属患病风险增加 可以延缓1型糖尿病的临床发作。DPT-1目前已获得资助 到2001年8月，审判网将被委托进行和完成 目前的协议。 我们的乔斯林/孩子？s中心致力于为未来的临床 1型糖尿病的治疗方法我们还提出了一种新的介入治疗方法， 方案，使用胰岛素B链在不完全弗氏？S佐剂在新 诊断为1型糖尿病患者，以测试其对β细胞的预防作用， 功能衰退。主要结果测量是混合餐刺激 C肽水平该研究的第一阶段目前正在进行中。

DESCRIPTION (provided by applicant) This is an application from the Joslin Diabetes Center/Children?s Hospital, a current Diabetes Prevention Trial-1 (DPT-1) Clinical Center to become a Clinical Center in the national diabetes trial network for Type 1 diabetes mellitus, the TrialNet. TrialNet, a national network of cooperative clinical research groups will consist of clinical centers and core support facilities. Its common goal will be to perform intervention studies to prevent, treat or ameliorate Type 1 diabetes mellitus in humans. TrialNet will also support natural history and genetic studies in the population screened or enrolled in specific studies aiming to achieve a better understanding of the etiology and pathogenesis of Type 1 diabetes and to develop strategies to prevent the disease. The Joslin Diabetes Center/Children?s Hospital proposed TrialNet Clinical Center includes expanded resources in experienced personnel, in addition to the expanded network of associated institutions to the collaborative effort led by the NIH. Our Clinical Center will have two major objectives: 1.) to complete the ongoing DPT-1 study; 2.) to participate in the design and implementation of existing and future pilot and expanded studies of new agents to prevent, treat or ameliorate Type 1 diabetes mellitus and also to participate and provide resources for genetic and natural history studies. The ongoing Diabetes Prevention Trial for Type 1 Diabetes (DPT-1) is testing, whether early intervention with parenteral or oral insulin in nondiabetic relatives of persons with Type 1 diabetes with increased risk for the disease can delay the clinical onset of Type 1 diabetes. The DPT-1 is currently funded through August 2001 and the TrialNet will be entrusted to carry on and complete the current protocol. Our Joslin/Children?s center is committed to contribute to future clinical studies in Type 1 diabetes mellitus. We also propose a novel interventional protocol, using insulin B-chain in incomplete Freund?s adjuvant in newly diagnosed Type 1 diabetes patients to test its preventive effect in beta cell function decline. The primary outcome measure is mixed meal stimulated C-peptide levels. Phase 1 part of the study is currently underway.