Physical Activity, Ovarian and Endometrial Cancer Risk

体力活动、卵巢癌和子宫内膜癌风险

• 批准号: 6588351
• 负责人: LESLIE BERNSTEIN
• 金额: $ 8.13万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6588351
• 关键词: body physical activity; cancer prevention; cancer risk; clinical research; data collection methodology /evaluation; human data; hysterectomy; neoplasm /cancer epidemiology; outcomes research; ovariectomy; ovary neoplasms; questionnaires; uterus neoplasms; women's health

DESCRIPTION (provided by applicant): Physical activity has numerous health benefits including a reduction in risk of colon and breast cancer. Physical activity may also alter the risk of endometrial cancer and epithelial ovarian cancer. Few studies have examined these potential relationships. Most prior studies have been case-control studies or record linkage studies that have used surrogate measures of activity. We propose to utilize data collected as part of the California Teachers Study (CTS), a cohort study of 133,479 female teachers and school administrators that was initiated in 1995, to address whether 1. Women who engage in moderate and strenuous physical activity for 4 or more hours per week on average, have a reduced risk of endometrial cancer and of ovarian cancer; 2. Strenuous physical activity provides greater protection against endometrial cancer and ovarian cancer than does moderate physical activity. Additionally we propose to analyze data collected from a group of population-based control subjects to compare their responses to the self-completed, mailed CTS questionnaire on physical activity to their responses to an in-depth, in-person interview that collected lifetime history of physical activity to determine whether the two types of questionnaires measure the same or different aspects of physical activity and to determine whether demographic or other factors affect the comparability of information derived from the two questionnaire approaches.

描述（由申请人提供）： 体育活动对健康有许多好处，包括降低患结肠癌和乳腺癌的风险。体力活动也可能改变子宫内膜癌和上皮性卵巢癌的风险。很少有研究探讨这些潜在的关系。大多数先前的研究都是病例对照研究或使用替代活动测量的记录关联研究。我们建议利用作为加州教师研究（CTS）的一部分收集的数据，该研究是1995年发起的一项对133，479名女教师和学校管理人员的队列研究，以解决是否 1.每周平均进行4小时或更长时间的中等强度和剧烈体力活动的妇女，患子宫内膜癌和卵巢癌的风险降低; 2.剧烈的体力活动比适度的体力活动更能预防子宫内膜癌和卵巢癌。 此外，我们建议分析从一组基于人群的对照组中收集的数据，将他们对自我完成的、邮寄的CTS体力活动问卷的回答与他们对一个深入的、在...中个人访谈，收集身体活动的终身史，以确定两种类型的问卷测量身体活动的相同或不同方面，并确定人口统计学或其他因素是否影响两种调查表方法所得信息可比性的因素。