Research and Mentoring on Energetic Factors and Cancer: Established Investigator

描述（申请人提供）：K 05奖将为Leslie伯恩斯坦博士提供40%的受保护时间（20%的研究，20%的指导）与学员一起研究身体活动与体型之间的关系（独立使用身高、体重、腰围和臀围测量值，以及各种比例测量值，如体重指数、腰臀比和腰高比）和乳房风险，子宫内膜癌、卵巢癌、肺癌、结肠癌、胰腺癌、膀胱癌、直肠癌和甲状腺癌、非霍奇金淋巴瘤和黑素瘤。伯恩斯坦博士在南加州大学（USC）有着长期成功的职业生涯，指导学生（本科生、硕士、博士）、博士后研究员、临床研究员和初级教师。在希望之城，伯恩斯坦博士将专注于指导人口科学、肿瘤内科和肿瘤外科系的初级教师和博士后研究员，鼓励他们追求癌症预防和控制方面的问题。她将继续指导南加州大学的博士和硕士学生，她是南加州大学的荣誉退休教授，以及克莱蒙研究生院新的社区和全球健康学院的硕士和博士生。研究的目标是鼓励学员专注于癌症发展或预后的风险因素，这些风险因素适合于生活方式干预，并考虑如何在人群中实施这些干预措施。具体的指导目标是促进学员的职业发展;为癌症病因学和预防方面的发展提供机会;促进对组织文化的理解;指导研究网络的发展，以促进职业目标;并就如何确定优先事项和提高效率提出建议。学员将在伯恩斯坦博士的精心指导下，利用加州教师研究队列（CA 077398，6/1/04-5/31/09，伯恩斯坦，PI）对133，479名自1995年以来因癌症事件而随访的妇女进行新的、无资金支持的研究领域。到目前为止，队列参与者已经完成了4份问卷，具有独特的特征，包括很少吸烟者（5%），获得医疗保健，大量使用激素治疗，不同的社会经济地位和居住背景，以及独特的生育史。学员将与伯恩斯坦博士合作，探讨身体活动与体型测量之间的相互作用问题，以确定乳腺癌总体和亚型的风险和预后，以及在足够数量的情况下，一系列其他癌症。进一步的学员将致力于开发一种方法，以扩大乳腺癌幸存者队列的数据收集，并为结肠癌和子宫内膜癌幸存者开展类似的研究工作，以研究身体活动和体重的变化如何影响生存，以及这些生活方式如何与饮食，补充药物的使用，疲劳，抑郁和生活质量相关。

DESCRIPTION (provided by applicant): The K05 award will provide Dr. Leslie Bernstein with 40% protected time (20% research, 20% mentoring) to pursue research with mentees on associations between physical activity and body size (using height, weight, waist and hip measurements, independently, and various ratio measures like body mass index, waist-hip ratio, and waist-height ratio) and risk of breast, endometrial, ovarian, lung, colon, pancreas, bladder, rectal and thyroid cancer, non-Hodgkin's lymphoma and melanoma. Dr. Bernstein has a long successful career mentoring students (undergraduate, MS, PHD) and postdoctoral fellows, clinical fellows, and junior faculty at the University of Southern California (USC). At the City of Hope, Dr. Bernstein will focus on mentoring junior faculty and postdoctoral fellows within the Departments of Population Sciences, Medical Oncology, and Surgical Oncology to encourage their pursuit of questions in cancer prevention and control. She will continue mentoring PhD and MS students at USC where she is Professor Emerita, and MPH and PhD students at the Claremont Graduate University's new School of Community and Global Health. The research goal is to encourage mentees to focus on risk factors for cancer development or prognosis that are amenable to lifestyle intervention and to consider how those interventions might be implemented in a population. Specific mentoring goals are to foster mentees career advancement; provide opportunities for growth in cancer etiology and prevention; promote understanding of organizational cultures; guide development of research networks to facilitate career goals; and advise on how to prioritize and be efficient. Mentees will pursue new, unfunded areas of research under the Dr. Bernstein's careful guidance using the California Teachers Study cohort (CA077398, 6/1/04-5/31/09, Bernstein, PI) of 133,479 women followed for incident cancers since 1995. Cohort participants have completed 4 questionnaires thus far and have unique characteristics which include few smokers (5%), access to health care, high use of hormone therapy, diverse socioeconomic status and residential backgrounds, and unique reproductive histories. Mentees will work with Dr. Bernstein to pursue questions on the interaction between physical activity and body size measures to define risk and prognosis for breast cancer overall and by subtype, and where sufficient numbers exist, a series of other cancers. Further mentees will work to develop an approach to expand data collection in a cohort of breast cancer survivors and develop similar research efforts for colon and endometrial cancer survivors to study how changes in physical activity and body weight affect survival and how these lifestyle practices are associated with diet, use of complementary medicines, fatigue, depression, and quality of life.