The Effect of ETOH and Folate on Hormone Related Cancers

乙醇和叶酸对激素相关癌症的影响

• 批准号: 6588621
• 负责人: ANNLOUISE R. ASSAF
• 金额: $ 7.47万
• 依托单位: MEMORIAL HOSPITAL OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6588621
• 关键词: alcoholic beverage consumption; body composition; breast neoplasms; clinical research; disease /disorder proneness /risk; female; folate; hormones; human data; human morbidity; human mortality; human subject; ovary neoplasms; postmenopause; questionnaires; uterus neoplasms; women's health

DESCRIPTION (provided by applicant): Introduction: The heavy, regular use of alcohol has been associated with significant morbidity and mortality, particularly in post-menopausal women. The consumption of high levels of alcohol has been associated with increased risk for breast, endometrial, and ovarian cancer. The risks associated with low to moderate alcohol consumption are much less clear. This may be due to differences in hormone replacement therapy or folic acid intake or to the difficulty associated with accurately assessing level of drinking. We hypothesize that high levels of alcohol use will be associated with a higher likelihood of developing breast, endometrial, and ovarian cancer and that folic acid intake will moderate the effect of alcohol on these cancers. Design: The Women's Health Initiative Observational Study cohort consists of 93,717 post-menopausal women who were enrolled between September 1993 until December 1998, nationwide. To date, there have been 1,999 incident cases of breast cancer, 253 cases of endometrial cancer, and 188 cases of ovarian cancer among the women enrolled in this study. Data regarding the use of alcohol, dietary folic acid, and the use of folic acid supplements was collected on each participant at baseline and again at a followup visit. We propose to conduct a secondary data analysis of the effect of alcohol consumption and folic acid intake on the risk of developing these hormone-related cancers. Conclusions: Breast cancer now ranks second in cancer deaths among United States' women and is a leading cause of morbidity. While the incidence of endometrial cancer is not as high, and because of early detection, mortality rates are low, endometrial cancer resulted in over 6,500 deaths in 2001. Ovarian cancer, though much less common, is associated with a very high mortality rate (approximately 50% for all stages) because it is often not detected until late stage. The Women's Health Initiative database provides a unique opportunity to explore the relationship of alcohol and folic acid intake with hormone-related cancers in post-menopausal women.

描述(由申请人提供)： 导言：经常大量饮酒与严重的发病率和死亡率有关，尤其是在绝经后的妇女中。大量饮酒会增加患乳腺癌、子宫内膜癌和卵巢癌的风险。与低度或中度饮酒相关的风险则不太清楚。这可能是由于激素替代疗法或叶酸摄入量的不同，或者与准确评估饮酒水平有关的困难。我们假设，高水平的饮酒与发生乳腺癌、子宫内膜癌和卵巢癌的可能性更高相关，而叶酸的摄入将缓和酒精对这些癌症的影响。 设计：妇女健康倡议观察性研究队列包括93,717名绝经后妇女，她们在1993年9月至1998年12月期间在全国范围内登记。到目前为止，在参与这项研究的女性中，已有1,999例乳腺癌，253例子宫内膜癌和188例卵巢癌。在基线和随访中收集了每个参与者的酒精使用、饮食叶酸和叶酸补充剂的使用数据。我们建议对酒精消费和叶酸摄入对发生这些激素相关癌症的风险的影响进行二次数据分析。 结论：乳腺癌目前在美国女性癌症死亡中排名第二，是发病率的主要原因。虽然子宫内膜癌的发病率并不高，而且由于早期发现，死亡率很低，但2001年子宫内膜癌导致了6500多人死亡。卵巢癌虽然不常见，但死亡率很高(在所有阶段约为50%)，因为它通常直到晚期才被发现。妇女健康倡议数据库为探索酒精和叶酸摄入与绝经后妇女激素相关癌症的关系提供了一个独特的机会。

项目成果

Alcohol and folate intake and breast cancer risk in the WHI Observational Study.

• DOI: 10.1007/s10549-008-0167-2
• 发表时间: 2009-08
• 期刊: BREAST CANCER RESEARCH AND TREATMENT
• 影响因子: 3.8
• 作者: Duffy, Christine M.;Assaf, Annlouise;Cyr, Michele;Burkholder, Gary;Coccio, Elizabeth;Rohan, Tom;McTiernan, Anne;Paskett, Electra;Lane, Dorothy;Chetty, V. K.
• 通讯作者: Chetty, V. K.